ArticleJournal of sleep research2025
Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.
Article in Journal of sleep research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The hypoxic burden algorithm: an integrated index for assessing intermittent hypoxia in pediatric obstructive sleep apnea-a retrospective cohort study.Translational pediatrics · 2026Article
- Early dynamic glucose dysregulation in obese adolescents with obstructive sleep apnea: a comparative analysis with fasting lactate.Journal of endocrinological investigation · 2026Article
- Hypoxic Burden in Children With Sleep-Disordered Breathing: Determinants and Correlates.Journal of sleep research · 2026Article
- Hypoxic burden as a cause of cardiovascular morbidity in childhood obstructive sleep apnea.Pediatric research · 2026Article
- Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.Journal of sleep research · 2025Article
- Cardiovascular complications in children with Down syndrome and sleep disordered breathing.Paediatric respiratory reviews · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Hypoxic burden (HB) is a measure incorporating frequency, depth and duration of respiratory event-related desaturations. While HB is associated with cardiovascular disease in adults with obstructive sleep apnea (OSA), it has not been assessed in typically developing (TD) children with OSA, nor in children with Down syndrome (DS), who have a higher incidence of OSA with more severe hypoxia. We assessed whether HB in these children was related to heart rate variability (HRV), an indicator of cardiovascular outcomes. Children (3-19 years, n = 44) with DS and TD children matched for OSA severity, age and sex underwent overnight polysomnography and were grouped into primary snoring (PS), Mild or Moderate/Severe (MS) OSA. HRV was analysed using power spectral analysis of the electrocardiograph. Regression analysis determined whether HB was predictive of HRV. Children with MS OSA in both groups had higher HB compared with children with PS (p < 0.001 for both) and Mild OSA (DS, p < 0.001; TD, p < 0.05). Children with DS and PS or Mild OSA had higher HB compared with TD children (PS p < 0.05; Mild OSA p < 0.001). There was no difference between the MS OSA groups. HB predicted dampened sympathetic and parasympathetic activity only in children with DS (R
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