ArticleJournal of cosmetic dermatology2025
Efficacy of Formulation With Potential as Herbal Medicine on Second Degree Burn Wound: Biochemical and Molecular Evaluation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Preclinical safety and efficacy of "Yubivaks," a natural ointment for burn wounds: acute dermal toxicity and irritancy evaluation.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurn injury is a condition caused by heat, cold, electricity, synthetic substances, and radiation, and it causes psychological and physical problems in the affected individuals.
aimsIn this study, it was aimed to investigate the healing effect of the spray formulation prepared using ethanol extracts of Olea europaea and Aloe vera leaves, Cocus nucifera fruit, and Chamomilla recutita flower plants (OACC) in a second-degree burn model created in rats, using biochemical and molecular parameters.
methodsExperimental groups were assigned to Healthy control (HC), Burn control (BC), Silver-Sulfadiazine (SS) and OACC. A deep second-degree burn was induced on the lower back and upper back of each rat under standard burning procedures, respectively. Experiments were performed using serum and skin tissue samples obtained on the 3rd-21st days after the burns were created. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were calculated. Transforming Growth Factor Beta-1 (Tgf-β1), Vascular Endothelial Growth Factor-alfa (Vegf-α), interleukin-6 (Il-6) and Tumor Necrosis Factor Alpha (Tnf-α) mRNA expression levels were determined using real-time polymerase chain reaction (RT-PCR).
resultsAOCC reduced the increased MDA levels in serum related to the burning event, while increasing the decreased SOD enzyme activity levels. In addition, AOCC decreased the gene expression levels of Tgf-β1 and Vegf-α, which are growth factors that were increased in the burn group, and Il-6 and Tnf-α, which are oxidative stress markers.
conclusionsWe believe that our study will shed light on the detailed examination of biochemical and molecular pathways affecting the wound healing process in future studies and will contribute to opening new doors for treatment.
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