ArticleJournal of Korean medical science2025
Association Between Serum Follicle-Stimulating Hormone Levels and Cognitive Function in Middle-Aged and Older Women.
Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Hormonal contraceptives impair psychomotor vigilance task performance under sleep deprivation with stress induction.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Amino acid profiles, aging, and sex hormone interactions in the elderly Iranian population: a metabolomics study.Journal of diabetes and metabolic disorders · 2025Article
- Differential role of anterior and posterior pituitary lobes in healthy aging and perceived stress.Scientific reports · 2025Article
- Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone.Frontiers in neuroscience · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearchers have proposed that there is a potential link between follicle-stimulating hormone (FSH) and cognitive function, yet the evidence remains inconclusive. The current study aims to identify the association between serum FSH levels and cognitive performance, and to examine whether this association varies by cognitive diagnosis, serum estradiol (E2) levels, or cognitive domain.
methodsThis multicenter cross-sectional study used a clinical database comprising female visitors to memory clinics at three referral hospitals in Korea. Venous blood samples were collected to determine serum FSH and E2 concentrations via immunoradiometric assay. Cognitive performance was evaluated using either the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease or the Seoul Neuropsychological Screening Battery, while cognitive diagnoses were made via clinical diagnostic interviews.
resultsAmong the 159 participants (normal cognition [NC], n = 70; mild cognitive impairment [MCI], n = 52; Alzheimer's disease [AD] dementia, n = 37), there were no significant differences in serum FSH levels associated with cognitive diagnosis. In women with NC, serum FSH levels were found to be positively correlated with cognitive performance in global cognition, nonverbal memory, and executive function, even after adjusting for serum E2 level and its interaction with serum FSH level. However, no significant correlations were observed in women with MCI and AD dementia.
conclusionThe association between circulating FSH and cognition may be independent from circulating E2, but it may depend on disease progression or cognitive domains. This suggests a potential role of gonadotropin in cognitive decline in elderly women.
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