Evidence map›Paper›PMID 40098477›Full record

ArticlePsychological medicine2025

Global burden of mental disorders in children and adolescents before and during the COVID-19 pandemic: evidence from the Global Burden of Disease Study 2021.

Yubo Liu, Yijun Ren, Chenxi Liu, Xiaoli Chen, Danlei Li, Jia Peng, Liao Tan, Qilin Ma

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Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

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24citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yubo LiuDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Yijun RenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Chenxi LiuDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Xiaoli ChenDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Danlei LiDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Jia PengDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Liao TanDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.ORCID 0009-0004-2936-4964
Qilin MaDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-8608-2219

Funding

Natural Science Foundation of Hunan Province 2022JJ30069
6 · The paper itself

Abstract

backgroundChildhood and adolescence are vulnerable periods for mental disorders, and the COVID-19 pandemic has exacerbated mental health challenges in this population. We aimed to estimate changes in the global burden of mental disorders among children and adolescents before and during the pandemic.

methodsUsing data from the Global Burden of Diseases Study 2021, we analyzed incidence, prevalence, and years lived with disability (YLDs) for mental disorders in individuals aged 5-24. Annual percent changes in age-standardized rates were calculated, and a Bayesian age-period-cohort model estimated the expected and additional burden based on pre-pandemic trends.

resultsIn 2021, an estimated 123.0 million new cases of mental disorders were reported among children and adolescents, with an 11.8% average annual increase in the age-standardized incidence rate during the pandemic. Anxiety disorders, which previously ranked third, became the leading cause of nonfatal disability (12.9 million [8.0-19.3] YLDs), while depressive disorders rose to fourth place (10.9 million [6.8-16.5] YLDs). The burden grew in most regions, especially among females, those aged 15-24, and in high sociodemographic index (SDI) areas. Based on pre-pandemic data, we estimated an additional burden of 795.0, 165.9, and 622.8 new cases per 100,000 population for total mental disorders, anxiety disorders, and depressive disorders globally in 2021, respectively. Spearman correlation analysis showed a significant positive correlation between additional burden and SDI levels.

conclusionsThese findings highlight the increased burden of mental disorders among children and adolescents during the pandemic, emphasizing the need for targeted post-pandemic mental health support.

Indexed as

COVID-19Global Burden of DiseaseMental DisordersAdolescentBayes TheoremChildChild, PreschoolFemaleGlobal HealthHumansIncidenceMalePrevalenceYoung Adultchildren and adolescentsCOVID-19Global Burden of Disease Studymental health

Identifiers

PMID40098477
PMCPMC12080646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.