ArticleACS applied materials & interfaces2025
Mapping Selenium Nanoparticles Distribution Inside Cells through Confocal Raman Microspectroscopy.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Highly robustFood chemistry: X · 2026Article
- Raman spectroscopic analysis of intracellular ice-induced degradation of mesenchymal stromal cells.Biophysical journal · 2026Article
- A novel solid-state approach for enhancing the antimicrobial and colorimetric properties of pine sawdust using selenium nanoparticles.Scientific reports · 2026Article
- Multifunctional Nanomaterial-Integrated Hydrogels for Sustained Drug Delivery: From Synthesis and Characterization to Biomedical Application.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium nanoparticles (SeNPs) exhibit significant potential in biomedical applications due to their antimicrobial, anticancer, and anti-inflammatory properties. In this study, we synthesized biocompatible SeNPs and employed confocal Raman microspectroscopy to map their distribution within human dermal fibroblast (HDF) cells. SeNPs possess a distinctive Raman band placed outside the cellular fingerprint region, which facilitates its detection and precise Raman imaging. Viability assays revealed that SeNPs exhibit cytotoxic effects only at the highest concentrations and for long exposure times while resulting in no harmful effects during all of the other treatments. For the first time, we achieved three-dimensional (3D) Raman mapping of SeNPs within cells, providing insights into their cellular penetration. Additionally, two-dimensional (2D) Raman mapping performed at different times and at sublethal concentrations demonstrated dynamic uptake and confirmed internalization. These findings highlight the effectiveness of SeNPs for biomedical imaging and therapeutic applications, offering an additional approach to studying nanoparticle-cell interactions.
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Registered trials
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