Evidence map›Paper›PMID 40098343›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2025

Sex Differences in B Cells From the Joints of Children With Oligoarticular Juvenile Idiopathic Arthritis.

Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn and 28 more

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Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

38 authors.

Ki Pui LamDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7414-2026
Claudia HarrisDivision of Immunology, Boston Children's Hospital, Boston, Massachusetts.
Maria L TaylorDivision of Immunology, Boston Children's Hospital, Boston, Massachusetts, and Wright State University Boonshoft School of Medicine, Dayton, Ohio.
Daniela Fernandez-SalinasDivision of Immunology, Boston Children's Hospital, Boston, Massachusetts, and Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.
Jing CuiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Biju IssacResearch Computing, Department of Information Technology Boston Children's Hospital, Boston, Massachusetts.
Liang SunResearch Computing, Department of Information Technology Boston Children's Hospital, Boston, Massachusetts.
Indu RamanDepartment of Immunology, Microarray & Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas.
Chengsong ZhuDepartment of Immunology, Microarray & Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas, Texas.
Maryrose HahnDivision of Immunology, Boston Children's Hospital, Boston, Massachusetts.
Maryam AshoorDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Ahmad BakhshDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Maria C BryantDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Siobhan CaseDivision of Immunology, Boston Children's Hospital and Harvard Medical School, and Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Mia ChandlerDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-2223-0061
Joyce C ChangDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Ezra CohenDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Fatma DedeogluDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-7516-0848
Olha HalyabarDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Jonathan S HausmannDivision of Immunology, Boston Children's Hospital and Harvard Medical School, and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.
Melissa HazenDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Daniel IbanezDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Liyoung KimDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Jeffrey LoDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Mindy S LoDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-2328-3536
Esra MeidanDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Megan PerronDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Helene PowersDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Mary Beth SonDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Holly WobmaDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8978-3184
Erin JanssenDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, and Department of Pediatrics, Michigan Medicine, Ann Arbor, Michigan.
Pui Y LeeDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-5779-4193
Peter A NigrovicDivision of Immunology, Boston Children's Hospital and Harvard Medical School, and Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-2126-3702
Laurie OhlmsDepartment of Otolaryngology & Communication Enhancement, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts.
A Eliot ShearerDepartment of Otolaryngology & Communication Enhancement, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts.
Margaret H ChangDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Maria Gutierrez-ArcelusDivision of Immunology, Boston Children's Hospital, Boston, Massachusetts, and Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.
Lauren A HendersonDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-0242-4029

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Bridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2M
T resident memory cells in arthritisR01AR075906 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2019 to 2023
$2.1M
T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritisR01AR083424 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Lauren A Henderson · 2024 to 2026
$1.5M
Cardiovascular health assessment & outcomes of systemic lupus erythematosus: bridging pediatric and adult-onset diseaseK23HL148539 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CHANG, JOYCE CHUN-LING · 2020 to 2024
$973k
Arthritis National Research FoundationCell Discovery NetworkLupus Research AllianceManton FoundationNHLBI NIH HHS K23 HL148539NHLBI NIH HHS K23HL148539NIAID NIH HHS T32 AI007512NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30AR070253NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01AR073201NIAMS NIH HHS R01 AR075906NIAMS NIH HHS R01AR075906NIAMS NIH HHS R01 AR083424NIAMS NIH HHS R01AR083424Samara Jan Turkel Clinical Center for Pediatric Autoimmune DiseaseVic Braden FamilyWarren Alpert Foundation
6 · The paper itself

Abstract

objectiveDisordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular (oligo) juvenile idiopathic arthritis (JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.

methodsB cells from the blood and synovial fluid (SF) of 44 children with oligo JIA were compared to those from the blood and tonsils of controls. Flow cytometry, B cell receptor (BCR) repertoire analysis, and autoantibody profiling were used to characterize B cells.

resultsMemory B (Bmem) cells and heterogeneous subsets of CD21

conclusionThese findings demonstrate prominent B cell dysregulation in oligo JIA and implicate sex as an important biologic factor in B cell responses in this disease.

Indexed as

Arthritis, JuvenileB-LymphocytesJointsMemory B CellsT-Lymphocytes, Helper-InducerAdolescentAutoantibodiesCase-Control StudiesChildChild, PreschoolFemaleFlow CytometryHumansMalePalatine TonsilReceptors, Antigen, B-CellAutoantibodiesReceptors, Antigen, B-Cell

Identifiers

PMID40098343
PMCPMC12313415

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