ReviewTherapeutic advances in respiratory disease
Advances in acute COPD exacerbation: clarifying specific immune mechanisms of infectious and noninfectious factors.
Review in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of diabetes mellitus on mortality in patients with acute exacerbation of chronic obstructive Pulmonary disease: a meta-analysis and systematic review.Frontiers in endocrinology · 2026Pooled it
- Pooled it
- Immune-inflammatory vulnerability index for risk stratification in older adults with acute exacerbations of COPD: a prospective cohort study.BMC geriatrics · 2026Observational
- One Index Does Not Predict All-Hematological Derived Indices Have Different Predictive Value for ICU Mortality in Critically Ill Patients with Non-Infectious Versus Infectious Acute Exacerbation of COPD.Medicina (Kaunas, Lithuania) · 2026Observational
- A rare case of lung abscess caused by Mycoplasma pneumoniae in an adult with chronic obstructive pulmonary disease.BMC infectious diseases · 2026Article
- Accurate Identification and Intervention System Construction of Treatable Traits in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Efficacy and mechanisms of andrographolide derivative in acute exacerbations of chronic obstructive pulmonary disease: a meta-analysis, network pharmacology, molecular docking, andFrontiers in pharmacology · 2026Article
- Article
- Beyond pathogens: a narrative review of the immunological nexus of damage-associated molecular patterns and inflammasome activation in sterile AECOPD.Frontiers in immunology · 2026Review
- A Decade of Healthcare Quality Assessment for Chronic Obstructive Pulmonary Disease in South Korea: Trends and Implications (2014-2023).Tuberculosis and respiratory diseases · 2025Article
- Habitat imaging radiomics of chest CT identifies noninfectious acute exacerbations in chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
- Immune markers for pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: a narrative review.Frontiers in immunology · 2025Review
- Mepolizumab for eosinophilic COPD with frequent exacerbations: single-centre real-world experience in a phenotype-directed approach.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main cause of hospitalization and death of patients with chronic obstructive pulmonary disease. This is largely due to bacterial resistance caused by clinical antibiotic abuse and the limited efficacy of current treatment strategies in managing noninfectious AECOPD, which presents a significant challenge for clinicians. Therefore, it is urgent for clinical treatment and prevention of AECOPD to fully understand the specific mechanism of AECOPD in the immune system and master the key differences between infectious factors and noninfectious factors. This article systematically discusses AECOPD triggered by various factors, including the activation of immune system, the recruitment and activation of inflammatory cells and the role of specific inflammatory responses, and through a comprehensive review of the literature, this article expounds the existing targeted diagnosis and treatment methods and technologies at different stages in order to provide new ideas and strategies for clinical prevention and treatment of AECOPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.