ArticleThe ISME journal2025
Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway.
Article in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Review
- Metabolite interactions mediate beneficial alliances between Bacillus and Trichoderma for effective Fusarium wilt control.The ISME journal · 2026Article
- Phage triggers spatial sporulation defense trade-offs.The ISME journal · 2026Article
- Antimicrobial effects of Bacillus safensis BS05 cell free supernatant against Campylobacter jejuni and its probiotic evaluation.BMC microbiology · 2026Article
- Probiotic effect of B. subtilis PS-216 in broiler chickens: modulation of weight, feed conversion, short chain fatty acids, microbiota and meat quality.Animal microbiome · 2025Article
- Fast-growingbioRxiv : the preprint server for biology · 2025Article
- ComK-induced cell death is reversed by upregulating the SigB or Spx pathway inMicrobiology spectrum · 2025Article
- Deciphering theJournal of bacteriology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The interactions between beneficial bacteria and pathogens are understudied. Here we investigate the interactions between the probiotic strain Bacillus subtilis PS-216 and the pathogen Salmonella Typhimurium SL1344. We show here that the sporulation of B. subtilis is impaired when it competes with S. Typhimurium in a nutrient-depleted medium. The sporulation impairment in B. subtilis is mediated by the sigma factor B (SigB)-dependent general stress response, as the ΔsigB mutant remains blind to manipulative cues from S. Typhimurium. Furthermore, we show that decreased sporulation frequency in B. subtilis depends on cell-cell contact between the two species involving the S. Typhimurium Type VI Secretion System, whereas B. subtilis uses the SigB-dependent response to trade spore quantity for higher spore quality.
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Registered trials
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