ArticleBMC cancer2025
Breast cancer care for the aging population: a focus on age-related disparities in breast cancer treatment.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dasatinib Cube-O-Needle hybrid system for effective and safe site-specific treatment for triple-negative breast cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Influence of obesity on breast cancer development in relation to menopausal status (Review).Molecular and clinical oncology · 2026Review
- The relationship between alexithymia, meaning in life, and quality of life in older breast cancer patients: a cross-sectional study based on variable-centered and person-centered perspectives.Frontiers in medicine · 2026Article
- Impact of Ethnic Differences and HER2 Protein Expression on the Age at Breast Cancer Diagnosis: A Mixed Methods Study.Cancer management and research · 2026Article
- Illuminating Bilateral Breast Cancer: A Multicenter Experience and Clinical Observations.Medicina (Kaunas, Lithuania) · 2025Article
- Breast cancer burden (1990-2040) in individuals aged 55 and above: a GBD 2021 analysis of global trends, sex-specific risk factors, and intervention impact.Frontiers in public health · 2025Article
- Beyond The Age Limit: A Comparative Study (<70 Vs ≥70 Years) in Breast Cancer Characteristics and Surgical Management in Women.Breast cancer (Dove Medical Press) · 2025Article
- Reasons for Perceived Everyday Discrimination, Quality of Life, and Psychosocial Health of Breast Cancer Survivors: A Cross-Sectional Cluster Analysis.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBreast cancer is a significant health issue for women worldwide and poses unique challenges for all ages. Older women face many concerns about breast cancer treatment and outcomes. This study aims to compare breast cancer management and outcomes across various age groups within a single-center experience in a region with an aging population, focusing specifically on women aged 70 and older to identify potential disparities in treatment and prognosis.
methodsWe conducted a retrospective analysis of all female patients diagnosed with breast cancer at our local reference Breast Unit in northeastern Italy between January 2002 and July 2023. The primary outcome measures in this study were overall survival (OS), disease-free survival (DFS), cumulative loco-regional recurrences, and cumulative distant recurrences.
resultsThe study included 2478 women over 70 (31.12%), 4690 women aged between 45 and 69 (58.90%), and 795 women under 45 (9.98%). According to the study, older women were more likely to have advanced-stage cancer, whereas they received less aggressive treatment, including fewer adjuvant therapies and surgical interventions. We also observed worse prognoses in this group of patients if compared with women aged 45 to 69 years. Moreover, data showed that the incidence of breast cancer among older women has increased over time.
conclusionsOur findings highlight the need for tailored treatment strategies for older breast cancer patients to balance treatment efficacy with quality-of-life considerations. These findings call for a strategic reevaluation of treatment protocols and emphasize the importance of personalized care, particularly for older women, to improve outcomes without sacrificing the quality of life while maintaining maximum survival potential.
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