ArticleBMC psychiatry2025
Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- mTORC1 Activation Links Chronic Stress to Meso-Circuit Desynchronization and Accelerated Amyloid Pathology via Autophagic Dysfunction.CNS neuroscience & therapeutics · 2026Article
- The Tryptophan-Kynurenine Pathway as a Key Mediator of the Gut-Brain Axis in Depression and Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Depression and Risk of Delirium in Older Adults: A Retrospective Cohort Study Using German Primary Care Data.Geriatrics (Basel, Switzerland) · 2026Article
- Depressive symptoms as a risk factor or prodrome of dementia: multi-state cognitive transitions modified by age and polygenic risk.The journal of prevention of Alzheimer's disease · 2026Article
- Evaluating the Impact of Cochlear Implantation on Cognitive Outcomes in Older Adults: A 5-Year Follow-Up.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- A systematic review and meta-analysis on dual-task sensor-based motion analysis for dementia detection.Frontiers in digital health · 2026Review
- A systematic review investigating the relationship between green and blue spaces and depression in older adults via DNA methylation.Environmental epigenetics · 2026Review
- Persistence and Determinants of Late-Life Depression: Results of the Nationally Representative Longitudinal German Aging Survey 2008 to 2023.International journal of geriatric psychiatry · 2025Article
- Variation in depression's impact on dementia risk by age in adults aged ≥75 years.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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5 authors.
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Abstract
backgroundDepression in late-life is linked to an increased risk of Alzheimer's dementia (AD), with the risk potentially varying according to the age at onset of depression. Previous studies have typically dichotomized depression onset ages between 55 and 65 years; however, the specific age at which depression onset increases AD risk in older adults remains unclear. In this study, we aimed to investigate the relationship between the age at onset of depression and AD risk, and compare the characteristics between different age groups.
methodsA longitudinal cohort of 251 older patients diagnosed with major depressive disorder was followed for up to 22 years. Participants were categorized into four groups based on depression onset age: ≤ 54 years, 55-64, 65-74, and ≥ 75 years. Annual cognitive assessments were conducted using the Korean Mini-Mental State Examination, with further neuropsychological testing when cognitive decline was suspected. Cox proportional hazards models were used to assess AD conversion risk across groups, adjusting for covariates.
resultsDuring follow-up ranging from 1.0 to 22.9 years, 75 patients (29.88%) converted to AD. Depression onset after age 75 years was significantly associated with a higher risk of AD conversion (hazard ratio [HR], 8.95; 95% confidence interval [CI], 3.41-23.48; p < 0.0001) and a shorter time to conversion compared to onset before age 55 (40.93 vs. 83.40 months). After adjusting for covariates, depression onset after age 75 remained significantly associated with AD conversion (adjusted HR, 5.20; 95% CI, 1.04-25.93; p = 0.0431). This group also had milder depressive symptoms and a higher prevalence of hypertension and cerebrovascular disease than those with depression onset before 55 years of age.
conclusionsThe onset of depression after the age of 75 years was strongly associated with an increased risk of AD and a shorter time to dementia onset. Individuals with depression onset after age 75 appear more closely linked to vascular comorbidities, while those with depression onset before age 55 are characterized by severe and recurrent depressive episodes. The mechanisms underlying AD in individuals with depression may differ from those in individuals without prior depression.
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