SynthesisBMC cancer2025
What is the impact of perineural invasion on the prognosis of cervical cancer: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Comparative evaluation of conventional radiomics and VGG-SAM fusion strategies for MRI-based preoperative prediction of perineural invasion in cervical cancer.Abdominal radiology (New York) · 2026Article
- Survival outcomes of postoperative radiotherapy and chemotherapy in early-stage cervical cancer: a Surveillance, Epidemiology, and End Results database-based stratified analysis.Translational cancer research · 2026Article
- [Interpretable machine learning models for preoperative precision prediction of perineural invasion in cervical cancer to support treatment decision: a multicenter retrospective study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- METTL3-mediated mScientific reports · 2026Article
- Perineural Invasion in Early-Stage Cervical Cancer: Marker of Aggressive Pathology and Increased Recurrence Risk.Biomedicines · 2026Article
- Development and validation of an interpretable machine learning model for postoperative radiotherapy decision-making in ypN0 breast cancer after neoadjuvant chemotherapy: a real-world study.BMC medical informatics and decision making · 2026Article
- Perineural invasion in solid tumors: biological foundations and the emerging integration of machine learning and artificial intelligence.Frontiers in oncology · 2026Review
- Natural Medicines Modulating Tumor Perineural Invasion: Regulatory Mechanisms and Therapeutic Potential.Drug design, development and therapy · 2026Review
- Low-molecular-weight metabolites from lactic acid bacteria suppress cervical cancer progression by inhibiting EMT via the Wnt/β-catenin pathway.Open life sciences · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPerineural Invasion (PNI) is a marker of a highly invasive tumor with poor prognosis, but the real influence on the prognosis of cervical cancer is still debated. We aimed to systematically investigate the prognostic impact of PNI in cervical cancer.
methodsWe searched PubMed, Embase, Cochrane databases, and ClinicalTrials.gov from inception to 20 April 2024. Cohort, case-control, and randomized controlled studies reporting the PNI status and survival outcomes of women with cervical cancer were included. Two reviewers extracted data independently and appraised study quality following the PRISMA guideline. The quality of the studies was assessed with Newcastle-Ottawa Scale. Random effect model was used if the heterogeneity was significant (P ≤ 0.1, I
resultsWe included seven retrospective cohort studies (1561 women) in the analysis. PNI was remarkably associated with a worse survival (risk ratio [95% CI]: 2.79 [1.67- 4.66], I
conclusionsPNI demonstrated a significant association with reduced overall survival in cervical cancer patients and emerged as a potential independent prognostic indicator, which provided a foundation for future investigations to evaluate the clinical utility of PNI status in guiding therapeutic strategies. TRAIL REGISTRATION: The protocol for this study was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) under identifying number CRD42022315970.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.