SynthesisScandinavian journal of trauma, resuscitation and emergency medicine2025
Prevalence and outcomes of hypocalcemia on ED arrival in traumatic patients before blood transfusions: a systematic review and meta-analysis.
Synthesis in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Admission ionised calcium disturbances and adverse outcomes in paediatric major trauma: a UK multicentre retrospective cohort study.BMJ open · 2026Article
- Survey of practices around the measurement and replacement of calcium in paediatric major trauma.BMJ paediatrics open · 2026Article
- A simplified prediction model for in-hospital mortality in children with congenital heart disease after surgery.Translational pediatrics · 2026Article
- Early transfusion strategies in haemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- A miniaturized mouse extracorporeal circulation model to characterize early hematologic and metabolic alterations.Frontiers in physiology · 2026Article
- Association between prognosis and calcium trajectories in patients with spinal cord injury based on MIMIC-IV data.Scientific reports · 2025Article
- Pre-hospital blood product transfusion and calcium management in the United Kingdom: a multicentre service evaluation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
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4 authors.
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Abstract
backgroundHypocalcemia represents a critical physiological disturbance in trauma-related hemorrhagic shock patients. Nonetheless, the prevalence and effects of hypocalcemia remain uncertain. This study aims to explore the prevalence of hypocalcemia before blood transfusions and its related mortality in adult patients with major traumatic injuries.
methodWe conducted a systematic search through databases, including PubMed, EMBASE, Scopus, and Web of Science, from their inception until June 30, 2024. Patients with major traumatic injuries whose serum calcium was measured upon arrival at the emergency department (ED) were included. We excluded those with prior blood transfusions, pre-clinical studies, review articles, and studies without a control group. Meta-analysis using a random-effect model was performed. Heterogeneity was evaluated using Cochrane Q and I² statistics. The study's risk of bias was assessed using the Joanna Briggs Institute's critical appraisal checklist. Publication bias was assessed using Egger's test and contour funnel plot visualization.
resultsOf the total, 1,984 abstracts were screened, leading to 15 studies in this review and meta-analysis. The overall prevalence of hypocalcemia upon ED arrival was 56% (95% CI 37%-74%), with high heterogeneity (I
conclusionHypocalcemia on ED arrival is common among adult trauma patients, who also exhibit a notably high mortality rate within this demographic. We recommend the monitoring of ionized calcium levels in traumatic adult patients. Furthermore, systematically designed studies examining the optimal thresholds, treatment protocols, and outcomes should be prioritized as the focal point of research.
trial registrationCRD42024549054 ( http://www.crd.york.ac.uk/PROSPERO ).
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