Evidence map›Paper›PMID 40098022›Full record

Observational studyBMC public health2025

Current and historic patterns of chronic disease burden are associated with physical activity and sedentary behavior in older adults: an observational study.

Mikael Anne Greenwood-Hickman, Rod L Walker, Abisola E Idu, John Bellettiere, David Wing, Susan M McCurry, Paul K Crane, Eric B Larson, Dori E Rosenberg, Andrea Z LaCroix

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mikael Anne Greenwood-HickmanKaiser Permanente Washington Health Research Institute, Seattle, WA, USA. mikael.anne.greewood-hickman@kp.org.
Rod L WalkerKaiser Permanente Washington Health Research Institute, Seattle, WA, USA. Rod.L.Walker@kp.org.
Abisola E IduKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
John BellettiereHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
David WingExercise and Physical Activity Resource Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Susan M McCurrySchool of Nursing, University of Washington, Seattle, WA, USA.
Paul K CraneSchool of Medicine, University of Washington, Seattle, WA, USA.
Eric B LarsonSchool of Medicine, University of Washington, Seattle, WA, USA.
Dori E RosenbergKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
NIA NIH HHS U01 AG006781NIA NIH HHS U01AG006781NIA NIH HHS U19 AG066567NIA NIH HHS U19AG066567
6 · The paper itself

Abstract

backgroundCross-sectional studies suggest that chronic disease burden in older adults is associated with lower activity. However, preceding life-course patterns of morbidity accumulation may also influence current activity and have not been well characterized. Using a well-described sample of older adults, we estimated associations between current chronic disease burden and accelerometer-measured moderate-to-vigorous intensity movement measures, light-intensity movement measures, and sedentary behavior measures. Additionally, we examined historic morbidity patterns among those with current multimorbidity to provide additional understanding of these later life associations between current multimorbidity and activity.

methodsAnalyses included N = 886 older adult study participants who wore activPAL and Actigraph accelerometers. We calculated Charlson Comorbidity Index (CCI; range 0-29) scores for participants at the time of device wear and estimated the association between current chronic disease burden (CCI

resultsA unit increment in CCI

conclusionsCurrent chronic disease burden was associated with moderate-to-vigorous intensity movement measures and some patterns of prolonged sitting. Current multimorbidity is characterized by a preceding pattern of accumulation over the life-course. Attention to both current and historic trajectory of multimorbidity is important in investigations of MVPA and health.

Indexed as

Cost of IllnessExerciseSedentary BehaviorAccelerometryAgedAged, 80 and overChronic DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedMultimorbidityAccelerometerCharlson comorbidity indexModerate-to-vigorous physical activity (MVPA)MultimorbiditySedentary behavior

Identifiers

PMID40098022
PMCPMC11917095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.