ArticleBMC ophthalmology2025
Longitudinal quantitative assessment of retinal crystalline deposits in bietti crystalline dystrophy.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bietti crystalline dystrophy in Türkiye: A genetic crossroads between Asia and Europe.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Fundus Autofluorescence as a Sensitive Biomarker of Disease Progression in Bietti Crystalline Dystrophy.Ophthalmology science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThis study aims to quantitatively analyze retinal crystalline deposits in patients with Bietti Crystalline Dystrophy (BCD) and examine their progression over time in a longitudinal study.
methodsWe retrospectively reviewed consecutive patients diagnosed with BCD at a single center. Retinal crystalline deposits were quantified from fundus photographs using semi-automated software, which divided the macular area into a central foveal circle, inner ring, and outer ring. We then analyze changes in the area and area fraction of these deposits over a two-year period.
resultsThe study included 30 eyes from 16 patients. Over the two-year study period, the inner ring demonstrated the statistically significant decrease in both crystal area and crystal area fraction from baseline to one year (P = 0.044 for area; P = 0.003 for area fraction) and two years (P = 0.003 for area; P < 0.001 for area fraction). Mean crystal area fraction was 1.042 ± 0.295% in the central foveal circle, 1.056 ± 0.208% in the inner ring, and 1.001 ± 0.155% in the outer ring, with no significant differences observed between the regions (all P > 0.05). The genotype-phenotype correlation showed that exon7del homozygotes had significantly lower baseline crystal area and area fraction, suggesting an association with more severe disease.
conclusionsThe use of semi-automated software to analyze fundus photographs provided a quantitative method for assessing retinal crystalline deposits in BCD. This longitudinal study enhanced our understanding of the disease's natural progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.