ArticleBMC pediatrics2025
Analysis of risk factors affecting prognosis of fulminant myocarditis in children: a ten-year single-center study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associated factors for in-hospital mortality in patients with fulminant myocarditis: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Article
- Early mortality-associated factors in pediatric fulminant myocarditis patients treated with venoarterial extracorporeal membrane oxygenation: a single-center retrospective cohort study.Translational pediatrics · 2026Article
- Clinical significance and mechanistic study of SOX2-OT and miR-27b-3p expression in children with viral myocarditis.BMC pediatrics · 2026Article
- Development and Validation of a Nomogram Model to Predict the Risk of Severe Pneumonia in Children with Pneumococcal Infection.Infection and drug resistance · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed to analyze the risk factors affecting the prognosis children with fulminant myocarditis.
methodsThe medical records of all patients (n = 40) who were diagnosed with fulminant myocarditis and admitted to the Cardiac Intensive Care Unit (CICU) and Pediatric Intensive Care Unit (PICU) at the Guanzhou Women and Children's Medical Center, Guangzhou Medical University between January 2014 and December 2023 were retrospectively analyzed. Patients were divided into two groups based on their in-hospital prognosis, namely, a survival group (n = 32) and an non-survival group (n = 8). Baseline demographics, laboratory findings, electrocardiograms, echocardiograms, and treatment regimens were compared between the two groups via multifactorial analysis.
resultsThe median age of patients in the survival group was 7.8 years (M[5,11.5]), and the median age in the non-survival group was 9.0 years (M[6,11.5]). Compared with those in the survival group, patients in the non survival group had significantly higher levels of extracorporeal cardiopulmonary resuscitation (ECPR) use, ventricular tachycardia/ventricular fibrillation (VT/VF), peak creatine kinase isoenzyme (CK-MB), peak N-terminal B-type natriuretic peptide precursor (NT-proBNP), serum creatinine (Scr) on admission, peak serum Scr, peak aspartate aminotransferase (AST), peak alanine aminotransferase (ALT), peak cardiac troponin I (cTnI), lactate on admission, peak lactate, and extracorporeal membrane oxygenation (ECMO) use (all p < 0.05). Binary logistic regression analysis revealed that the peak lactate level was an independent risk factor for mortality in patients with fulminant myocarditis (OR = 0.661, 95% CI 0.488-0.897; p = 0.008).
conclusionsThe present study demonstrated that the peak lactate level is an independent risk factor for mortality in patients with fulminant myocarditis.
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