SynthesisBMC geriatrics2025
Evidence on non-pharmacological interventions for preventing or reversing physical frailty in community-dwelling older adults aged over 50 years: overview of systematic reviews.
Synthesis in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence on non-pharmacological interventions for preventing or reversing physical frailty in community-dwelling older adults aged over 50 years: overview of systematic reviews.BMC geriatrics · 2025Pooled it
- A hybrid type 1 trial of a digital behaviour change intervention for frailty prevention in community-dwelling older adults aged 60 years and older.Age and ageing · 2026Trial
- Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- External Validation of a Community Pharmacy-Based Screening Tool for Frailty That Uses Routinely Collected Data.Drugs & aging · 2026Article
- Associations Between Physical Activity, Muscle Mass, and Functional Outcomes in Community-Dwelling Older Adults from Chile: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2026Article
- [Interactions between nutrition and frailty].Innere Medizin (Heidelberg, Germany) · 2025Review
- Gaming Against Frailty: Effects of Virtual Reality-Based Training on Postural Control, Mobility, and Fear of Falling Among Frail Older Adults.Journal of clinical medicine · 2025Article
- Physical Inactivity Syndrome: A Risk Factor and Target for Intervention-A Narrative Review.Progress in rehabilitation medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundA large proportion of older adults are pre-frail. Interventions aimed at this group provide opportunity to reduce progression of physical frailty. The aim of this overview of reviews is to evaluate evidence for non-pharmacological interventions for the prevention/reversal of physical frailty in community-dwelling adults aged ≥ 50 years.
methodsMedline, Embase, CINAHL, Cochrane Database of Systematic Reviews, Google Scholar and Social Science Citation Index were searched for non-pharmacological interventions that used a validated frailty measurement tool. Review quality was assessed using AMSTAR-2 and a Synthesis Without Meta-analysis (SWiM) approach was adopted.
resultsTwenty-three reviews were included, six of which were of high quality. This included 18,768 unique participants from 98 unique primary studies. Physical activity containing an aspect of resistance training, for a minimum of twice per week, was evidenced as being beneficial for reversing frailty (28 primary studies and 3,246 unique participants). However, one randomised controlled trial (RCT) showed resistance training by pre-frail adults (n = 66) for eight weeks was not effective at reversing frailty status. Nutrition interventions combined with physical activity that include resistance training (9 studies, 1,812 participants) were effective at reversing/preventing frailty.
conclusionThe evidence synthesised in this overview of reviews suggests physical activity containing an aspect of resistance training is beneficial at reversing frailty status and preventing frailty progression. Nutrition interventions alone were inconclusive. It is recommended that future studies include a validated tool to assess frailty status, report samples by frailty status and make recommendations based on dose (frequency/duration of minutes per session) and adherence to dose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.