ArticleOrganic letters2025
Merging Ketyl Radical Chemistry and Allylboration via Strain Release: One-Pot Multicomponent Access to Sterically Congested Ketone-Functionalized Organoborons.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Borylcyclopropanes: Synthetic Strategies and Applications.Angewandte Chemie (International ed. in English) · 2026Review
- Photochemical strategies in divalent samarium catalysis.Beilstein journal of organic chemistry · 2026Review
- Contemporary Strategies in SmIAngewandte Chemie (International ed. in English) · 2025Review
- Palladium-Catalyzed Gem-Diborylalkylation of Silyl Enol Ethers and N-Vinylacetamide via Diboryl Carbon-Centered Radicals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- SmIAngewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Ketyl radical-mediated ring opening and [2σ+2π] cycloaddition of cyclopropyl ketones (CPKs) with alkynes typically require activation by alkyl, aryl, or carbonyl groups yielding cyclopentenes having one or two non-adjacent stereocenters. We developed a one-pot multicomponent reaction of diboryl-activated CPKs with alkynes and aldehydes that merges ketyl radical chemistry with allylboration. This method enabled highly diastereoselective access to densely functionalized cyclopentenes featuring homoallylic alcohol, ketone, and alkenyl boronate motifs on adjacent quaternary, tertiary, and secondary stereogenic centers. Additionally, diboryl CPKs also allowed the synthesis of rare ketone-functionalized γ,γ-disubstituted allylic diborons.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.