Evidence map›Paper›PMID 40097910›Full record

ArticleJournal of neuromuscular diseases2025

Visualizing ambulatory performance by age and rates of decline among patients with Duchenne muscular dystrophy.

Anna G Mayhew, James Signorovitch, Michaela Johnson, Molly Frean, Susan J Ward, Nate Posner, Valeria Merla, Matthias Mahn, Georgia Stimpson, Michela Guglieri and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anna G MayhewThe John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, UK.
James SignorovitchAnalysis Group, Inc., Boston, MA, USA.
Michaela JohnsonAnalysis Group, Inc., Boston, MA, USA.
Molly FreanAnalysis Group, Inc., Boston, MA, USA.
Susan J WardCollaborative Trajectory Analysis Project (cTAP), Cambridge, MA, USA.
Nate PosnerPfizer, Inc., New York, NY, USA.
Valeria MerlaPfizer, Inc., New York, NY, USA.
Matthias MahnPfizer, Inc., New York, NY, USA.
Georgia StimpsonThe Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
Michela GuglieriThe John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Volker StraubThe John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Robert Muni-LofraThe John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, UK.
Adnan ManzurThe Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
Giovanni BaranelloThe Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
Francesco MuntoniThe Dubowitz Neuromuscular Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
North Star Clinical Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Duchenne muscular dystrophy (DMD), age at symptom onset and rate of decline thereafter vary considerably. This study contrasted disease progression over time using the North Star Ambulatory Assessment (NSAA) in an overall sample of patients with DMD (mean age 7.1 years; baseline total NSAA score 22.2) with that of a centrally representative subgroup (mean age 6.9 years; NSAA score 24.0) defined according to median age at loss of ambulation. The average disease trajectory in the overall sample understated the more rapid rates of decline experienced by patients in the centrally representative subgroup.

Indexed as

Muscular Dystrophy, DuchenneWalkingAdolescentAge FactorsChildChild, PreschoolDisease ProgressionHumansMaleambulationdisease progressionDuchenne muscular dystrophyNorth Star Ambulatory Assessmentvisualization

Identifiers

PMID40097910
PMCPMC13142856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.