ArticleNature genetics2025
Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.
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Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2citing papers in PubMed, 1 pooled it
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Cortical morphometric inverse divergence in attention-deficit/hyperactivity disorder correlates with cell-type-specific, laminar-specific and developmental transcriptomic signatures.Psychological medicine · 2026Article
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Authors and funding
46 authors.
Yuan Ji *Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0003-2874-5904
Nana Liu *Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Yunjun Yang *Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Meiyun WangDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.ORCID http://orcid.org/0000-0003-4454-5005
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID http://orcid.org/0000-0001-9944-8419
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0001-6252-9450
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.ORCID http://orcid.org/0000-0002-6739-4265
Zuojun GengDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.
Hui ZhangDepartment of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China.
Bo GaoDepartment of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-0127-2812
Tong HanDepartment of Radiology, Tianjin Huanhu Hospital, Tianjin, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
Wen QinDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0002-9121-8296
Feng LiuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0002-3570-4222
Meng LiangSchool of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China.
Sijia WangDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0001-8949-303X
Qiang XuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Jiayuan XuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0001-9473-1047
Jilian FuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Dapeng ShiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China.
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Su LuiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.ORCID http://orcid.org/0000-0002-9129-7895
Jing ZhangDepartment of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, Tianjin, China.
Yanwei MiaoDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9311-0297
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7541-0130
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.ORCID http://orcid.org/0000-0001-5407-5671
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0001-9110-585X
Longjiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID http://orcid.org/0000-0002-6664-7224
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.ORCID http://orcid.org/0000-0003-3157-8393
Mulin Jun LiDepartment of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID http://orcid.org/0000-0003-3598-3679
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. cjr.xianjunfang@vip.163.com.ORCID http://orcid.org/0000-0003-2191-9393
Bing ZhangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. zhangbing_nanjing@vip.163.com.ORCID http://orcid.org/0000-0002-3953-0290
Chunshui YuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.ORCID http://orcid.org/0000-0001-5648-5199
CHIMGEN Consortium
Funding
National Natural Science Foundation of China (National Science Foundation of China) 81425013National Natural Science Foundation of China (National Science Foundation of China) 82030053National Natural Science Foundation of China (National Science Foundation of China) 82330059National Natural Science Foundation of China (National Science Foundation of China) 82371924National Natural Science Foundation of China (National Science Foundation of China) 82460063
Abstract
The amygdala is a small but critical multi-nucleus structure for emotion, cognition and neuropsychiatric disorders. Although genetic associations with amygdala volumetric traits have been investigated in sex-combined European populations, cross-ancestry and sex-stratified analyses are lacking. Here we conducted cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in 6,923 Chinese and 48,634 European individuals. We identified 191 variant-trait associations (P < 2.38 × 10
Indexed as
AmygdalaGenome-Wide Association StudyAdultEast Asian PeopleFemaleHumansMaleMiddle AgedOrgan SizePolymorphism, Single NucleotideQuantitative Trait LociSex CharacteristicsSex FactorsWhite People
Identifiers
PMID
40097784What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.