Evidence map›Paper›PMID 40097732›Full record

ReviewTopics in current chemistry (Cham)2025

Recent Advances in the Mitsunobu and Related Reactions: A Review from 2010 to 2024.

Abdeslem Bouzina, Zineb Aouf, Aϊcha Amira, Yousra Ouafa Bouone, Houria Bentoumi, Yasmine Chemam, Malika Ibrahim-Ouali, Rachida Zerrouki, Nour-Eddine Aouf

Abstract readReview
PubMed Publisher
In one paragraph

Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdeslem BouzinaLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria. abdeslem.bouzina@univ-annaba.dz.ORCID http://orcid.org/0000-0002-8908-8912
Zineb AoufLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria.ORCID http://orcid.org/0000-0002-3873-8647
Aϊcha AmiraLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria.ORCID http://orcid.org/0000-0003-4362-8386
Yousra Ouafa BouoneLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria.ORCID http://orcid.org/0000-0002-3202-5304
Houria BentoumiLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria.ORCID http://orcid.org/0000-0002-2663-1201
Yasmine ChemamLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria.ORCID http://orcid.org/0000-0001-7826-3925
Malika Ibrahim-OualiAix Marseille Univ, Marseille, France.ORCID http://orcid.org/0000-0001-7272-9392
Rachida ZerroukiUniv. Limoges, LABCiS, UR 22722, 87000, Limoges, France.ORCID http://orcid.org/0000-0002-2311-7901
Nour-Eddine AoufLaboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Chemistry Department, Faculty of Sciences, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria. aoufnoureddine18@gmail.com.ORCID http://orcid.org/0000-0003-2705-8184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review discusses recent progress in the most significant synthetic approaches involving transformations under the Mitsunobu reaction. The Mitsunobu reaction entails the "redox" condensation of an acidic pronucleophile 'Nu-H' and an electrophilic primary or secondary alcohol, facilitated by stoichiometric amounts of phosphines and azodicarboxylate reagents. Widely utilized for dehydrative oxidation-reduction condensation, this reaction shows synthetic utility through its tolerance of a broad range of acidic pronucleophiles, including carboxylic acids, pro-imides, hydroxamates, phenols, thiols, fluorinated alcohols, oximes, thioamides, pyridinium and imidazolium salts, pyrimidine bases, α-ketoesters, and trimethylmethane tricarboxylate, thereby yielding a variety of functional and potentially biologically active compounds. The purpose of this review is to focus on recent advances and applications of Mitsunobu reaction chemistry, particularly from 2010 to 2024. In addition to discussing newer reagents that facilitate purification, we will describe contemporary applications of this chemistry, especially concerning the synthesis of potential biological compounds and their precursors. This focus review of the Mitsunobu reaction summarizes its origins, the current understanding of its mechanism, and recent improvements and applications. We aim for this work to serve as a useful resource for scientists working in this research domain.

Indexed as

Oxidation-ReductionMolecular StructureC-alkylationCarboxylic acids pronucleophileMitsunobu reactionN-alkylationO-alkylationS-alkylation

Identifiers

PMID40097732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.