Evidence map›Paper›PMID 40097731›Full record

ArticleScientific reports2025

Bisdemethoxycurcumin chemoprevents 7,12-dimethylbenz(a)anthracene-induced mammary toxicity via modulation of oxidative processes.

Adedoyin O Adefisan-Adeoye, Oluwaferanmi O Ayanbanjo, Temitope D Adeoye, Taiwo E Jayesimi, Jeremiah O Unuofin, Sogolo L Lebelo, Oluwatosin A Adaramoye

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adedoyin O Adefisan-AdeoyeChemical Sciences Department, Faculty of Computing and Applied Sciences, Dominion University Ibadan, Ibadan, Nigeria. adedoyinadefisan22@gmail.com.
Oluwaferanmi O AyanbanjoChemical Sciences Department, Faculty of Computing and Applied Sciences, Dominion University Ibadan, Ibadan, Nigeria.
Temitope D AdeoyeFederal Teaching Hospital, Ido Ekiti, Nigeria.
Taiwo E JayesimiChemical Sciences Department, Faculty of Computing and Applied Sciences, Dominion University Ibadan, Ibadan, Nigeria.
Jeremiah O UnuofinDepartment of Life and Consumer Sciences, Florida Campus, University of South Africa, Johannesburg, South Africa.
Sogolo L LebeloDepartment of Life and Consumer Sciences, Florida Campus, University of South Africa, Johannesburg, South Africa.
Oluwatosin A AdaramoyeMolecular Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisdemethoxycurcumin (BDMC) is a naturally occurring compound having anti-cancer properties. We investigated the effect of BDMC on DMBA-induced mammary toxicity in female Wistar rats. Forty-eight virgin female rats were divided into six groups at random. Group 1 received corn oil, group 2 received DMBA (50 mg/kg), groups 3 and 4 received DMBA and BDMC (25 mg/kg and 50 mg/kg), group 5 received BDMC (50 mg/kg), and group 6 received DMBA and vincristine. A single dosage of DMBA was administered (i.p.) at six weeks, followed by BDMC (orally) and vincristine (i.p.) three times a week for thirteen weeks. The DMBA significantly increased lactate dehydrogenase activity by 1.3 folds. Similarly, DMBA increased nitric oxide, malondialdehyde, and myeloperoxidase activities by 12, 204, and 6.3%, respectively. DMBA-rats decreases glutathione-S-transferase, superoxide dismutase, and glutathione peroxidase activities. Immunohistochemistry analysis revealed that B-cell lymphoma-2, estrogen receptor, and human epidermal receptor-2 were strongly expressed in DMBA-rats, but progesterone receptor and Bcl-2 associated protein were weakly expressed. In DMBA rats, histology revealed mammary glands with moderate proliferating ducts and fibrosis. Co-treatment with BDMC reduces hormone receptors activities, improved antioxidant and apoptotic status. BDMC protected the mammary gland from DMBA toxicity by targeting cellular pathways involved in oxidative stress and apoptosis.

Indexed as

9,10-Dimethyl-1,2-benzanthraceneCurcuminDiarylheptanoidsMammary Glands, AnimalOxidative StressAnimalsApoptosisFemaleMalondialdehydeNitric OxideOxidation-ReductionRatsRats, WistarSuperoxide Dismutase9,10-Dimethyl-1,2-benzanthracenebisdemethoxycurcuminCurcuminDiarylheptanoidsMalondialdehydeNitric OxideSuperoxide DismutaseAntioxidantsApoptosisBisdemethoxycurcuminDimethylbenz(a)anthraceneHormone receptorsInflammationOxidative stress

Identifiers

PMID40097731
PMCPMC11914581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.