Evidence map›Paper›PMID 40097629›Full record

ArticleScientific reports2025

The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes.

Afaf D Abdel Mageid, Ibrahim M Abdel-Wadoud, Elsayed I Salim, Thamer Aljutaily, Hassan Barakat, Huda Aljumayi, Khadija S Radhi, Sami O Almutairi, Tarek A Ebeid

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Afaf D Abdel MageidBiochemistry and Molecular Biology, Faculty of Veterinary Medicine, Benha University, Moshtohor, 13736, Egypt.
Ibrahim M Abdel-WadoudBiochemistry and Molecular Biology, Faculty of Veterinary Medicine, Benha University, Moshtohor, 13736, Egypt.
Elsayed I SalimDepartment of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
Thamer AljutailyDepartment of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, 51452, Buraydah, Saudi Arabia.
Hassan BarakatDepartment of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, 51452, Buraydah, Saudi Arabia. haa.mohamed@qu.edu.sa.
Huda AljumayiDepartment of Food Science and Nutrition, College of Sciences, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
Khadija S RadhiDepartment of Food Science and Nutrition, College of Sciences, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
Sami O AlmutairiQassim Health Cluster, Ministry of Health, Riyadh, Saudi Arabia.
Tarek A EbeidDepartment of Animal and Poultry Production, College of Agriculture and Food, Qassim University, 51452, Buraydah, Saudi Arabia.

Funding

Qassim University QU-APC-2025
6 · The paper itself

Abstract

Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as a protective and chemotherapeutical substance in combating this lethal condition, either independently or in conjunction with tamoxifen therapy. Breast cancer in mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 mice in each group. (i) control group, (ii) carcinogenic group, (iii) tamoxifen-treated group, (iv) Amygdalin-treated group, (v) (Amygdalin + tamoxifen) group, (vi) Amygdalin protective group. Results revealed that DMBA-induced breast cancer caused a significant increase in biochemical parameters such as CEA, CA15.3, CA125, PRL, E2, urea, creatinine, ALT, AST, and ALP and a substantial increase in gene expression of TNF-α and BcL-2. In contrast, amygdalin administrations alone or in co-administration with tamoxifen could ameliorate breast cancer by declining TNF-α, BcL-2 and attenuating the biochemical parameters. Amygdalin administrations showed a significant increase in SOD and GPx antioxidants and upregulation of Caspase-3 and P53 in breast tissue. Moreover, flow cytometric analysis revealed that amygdalin administrations were correlated with CD20 and CD44 and promoted the cell cycle and apoptosis in carcinogenic mice. Indeed, the above results were confirmed by the histopathological examinations, which showed that the DMBA group had proliferated microductular carcinoma with marked mononuclear inflammatory cell infiltration, which decreased by the Amygdalin administrations. In conclusion, amygdalin administration may be effective in preventing breast cancer and exhibiting chemotherapeutic properties.

Indexed as

AmygdalinGene Expression Regulation, NeoplasticMammary Neoplasms, Experimental9,10-Dimethyl-1,2-benzanthraceneAnimalsApoptosisFemaleMiceTamoxifenUp-Regulation9,10-Dimethyl-1,2-benzanthraceneAmygdalinTamoxifenAmygdalinBcL-2Cancer therapyCaspase-3HealthMammary cancerP53ProtectiveTamoxifenTNF-α

Identifiers

PMID40097629
PMCPMC11914690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.