ArticleNature structural & molecular biology2025
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.
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Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- A ubiquitin chain-feeding mechanism for BRCA1-A.Nature communications · 2026Article
- Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex.Nature communications · 2026Article
- Coupling proteostasis andTheranostics · 2026Article
- One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy.Cancer metastasis reviews · 2025Review
- Complexes Formed by the K63-Specific Deubiquitinating Enzyme BRCC36: New Promising Therapeutic Targets in Human Disease.Biomolecules · 2025Review
- High-throughput investigation of macromolecular interactions for drug development using spectral shift technology.Biophysical reviews · 2025Review
- Unraveling chain specific ubiquitination in cells using tandem ubiquitin binding entities.Scientific reports · 2025Article
Corrections and comments
- Update of
Authors and funding
24 authors.
Francesca ChandlerAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-3465-7599
Poli Adi Narayana ReddyMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program and The Wistar Cancer Center Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Smita BhutdaDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca L RossLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Arindam DattaDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Miriam WaldenAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Kieran WalkerLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-6694-2979
Stefano Di DonatoLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Joel A CasselMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program and The Wistar Cancer Center Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Michael A PrakeschDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2960-6471
Ahmed AmanDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0275-205X
Alessandro DattiDepartment of Agricultural, Food, and Environmental Sciences, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0001-6824-7382
Lisa J CampbellAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Martina FoglizzoAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0001-9132-4737
Lillie BellAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0009-0001-9398-4031
Daniel N SteinDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James R AultAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Rima S Al-AwarDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Antonio N CalabreseAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-2437-7761
Frank SicheriCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9824-2117
Francesco Del GaldoLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK. F.DelGaldo@leeds.ac.uk.ORCID http://orcid.org/0000-0002-8528-2283
Joseph M SalvinoMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program and The Wistar Cancer Center Molecular Screening, The Wistar Institute, Philadelphia, PA, USA. jsalvino@wistar.org.ORCID http://orcid.org/0000-0002-2184-5980
Roger A GreenbergDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. rogergr@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-1326-8981
Elton ZeqirajAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. e.zeqiraj@leeds.ac.uk.ORCID http://orcid.org/0000-0003-0239-5926
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MThe RAP80-BRCC36 Deubiquitinating Complex in DNA RepairR01CA138835 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2010 to 2026
$5.2MPurchase of an Echo 650 acoustic liquid handler with Access workstationS10OD030245 · OD · WISTAR INSTITUTE · PI SALVINO, JOSEPH M · 2021 to 2021
$567kNCI NIH HHS P30 CA010815NCI NIH HHS R01 CA138835NIH HHS S10 OD030245Wellcome Trust 220628
Abstract
Deubiquitylases (DUBs) are crucial in cell signaling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signaling by cleaving K63-linked polyubiquitin chains on type I interferon receptors (IFNAR1). As a Zn
Indexed as
Deubiquitinating EnzymesEnzyme InhibitorsInflammationSignal TransductionCatalytic DomainCrystallography, X-RayHEK293 CellsHumansModels, MolecularProtein MultimerizationReceptor, Interferon alpha-betaUbiquitinationDeubiquitinating EnzymesEnzyme InhibitorsReceptor, Interferon alpha-beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.