ArticleScientific reports2025
Association of novel inflammatory markers with osteoporosis index in older spine osteoporosis patients: NHANES 1999-2018 cross-sectional study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Prognostic value of nine inflammatory biomarkers for 30-day mortality in critically ill elderly patients with osteoporotic hip fracture.Scientific reports · 2026Article
- Association Between Three Systemic Inflammatory Biomarkers and Diabetic Foot Ulcer: A Cross-Sectional Study and a Clinical Retrospective Study.Mediators of inflammation · 2026Article
- The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross-Sectional Study.Mediators of inflammation · 2026Article
- Association between platelet-to-albumin ratio and total spine bone mineral density in older adults with thoracolumbar fragility fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Traditional clinical risk factors outperform disease activity and hematologic indices for FRAX hip fracture risk in rheumatoid arthritis.Frontiers in immunology · 2026Article
- Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis.International journal of molecular sciences · 2025Article
- Exploring the Association Between Platelet Count, the Systemic Immune Inflammation Index, and Fracture Risk in Postmenopausal Women with Osteoporosis: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Association between pan-immune-inflammation value and bone turnover markers in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in medicine · 2025Article
- Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support.Frontiers in medicine · 2025Article
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11 authors.
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Abstract
This study aimed to examine the relationships of osteoporosis with Osteoporosis indices in elderly patients, and investigate the associations of novel inflammatory markers with variations of Osteoporosis indices. Senior citizens were recruited from the National Health and Nutrition Examination Survey (NHANES). Dual-energy X-ray absorptiometry was used to detect bone mineral density tests. Osteoporosis indices and diagnosis of osteoporosis were evaluated using multivariate weighted logistic regression models. Novel inflammatory markers were calculated based on lymphocyte, neutrophil, monocyte, platelet, and albumin counts. The relationships between the Osteoporosis indices and novel inflammatory markers were evaluated with multivariate weighted logistic regression models. Totally 837 elderly patients were enrolled, including 494 men and 343 women, and their weighted average age was 68.28 ± 7.60 years. Our results indicated that the osteoporosis indices were positively correlated with the presence of osteoporosis and that these three indices measured the severity of osteoporosis. After multivariate weighted logistic regression model analysis of the novel inflammatory markers and osteoporosis index, AIRI, SIRI, and SII were significantly correlated with the osteoporosis indices. There may be a close relationship between inflammation and senile osteoporosis. The novel inflammatory markers are convenient and objective for predicting low BMD or osteoporosis risk in older patients. Among these markers, elderly patients with high levels of AISI, SIRI, and SII should focus on the risk of osteoporosis. However, this study has some limitations. It is essential to expand the sample size to a wider population to investigate the relationship between inflammation and osteoporosis.
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