ArticleScientific reports2025
MRI distortion correction is associated with improved local control in stereotactic radiotherapy for brain metastases.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical and MRI factors influencing interobserver delineation variability of brain metastases before stereotactic radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
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15 authors.
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Abstract
Distortions in brain MRI caused by gradient nonlinearities may reach several millimeters, thus distortion correction is strongly recommended for radiotherapy treatment planning. However, the significance of MRI distortion correction on actual clinical outcomes has not been described yet. Therefore, we investigated the impact of planning MRI distortion correction on subsequent local control in a historic series of 419 brain metastases in 189 patients treated with stereotactic radiotherapy between 01/2003 and 04/2015. Local control was evaluated using a volumetric extension of the RANO-BM criteria. The predictive significance of distortion correction was assessed using competing risk analysis. In this cohort, 2D distortion-corrected MRIs had been used for treatment planning in 52.5% (220/419) of lesions, while uncorrected MRIs had been employed in 47.5% (199/419) of metastases. 2D distortion correction was associated with improved local control (Cumulative incidence of local progression at 12 months: 14.3% vs. 21.2% and at 24 months: 18.7% vs. 28.6%, p = 0.038). In multivariate analysis, adjusting for histology, baseline tumor volume, interval between MRI and treatment delivery, year of planning MRI, biologically effective dose and adjuvant Whole-brain radiotherapy, use of distortion correction remained significantly associated with improved local control (HR 0.55, p = 0.020). This is the first study to clinically evaluate the impact of MRI gradient nonlinearity distortion correction on local control in stereotactic radiotherapy for brain metastases. In this historic series, we found significantly higher local control when using 2D corrected vs. uncorrected MRI studies for treatment planning. These results stress the importance of assuring that MR images used for radiotherapy treatment planning are properly distortion-corrected.
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