ArticleNature communications2025
Comparative genomics provides insights into the biogeographic and biochemical diversity of meliaceous species.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Identification of intraspecific cultivarFrontiers in plant science · 2026Article
- Analysis of a near telomere-to-telomere genome of Phellodendron amurense reveals insights into berberine biosynthesis.Nature communications · 2025Article
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9 authors.
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Abstract
Meliaceous plants such as Azadirachta indica (neem) and Melia azedarach (chinaberry) contain large amounts of limonoids with unique anti-insect activities. However, genes responsible for downstream modifications of limonoids are not well known. Here, we improve the genome assemblies of neem and chinaberry to the telomere-to-telomere (T2T) level. Allopatric speciation of the two plants is confirmed by the lineage-specific inversion of chromosome 12 in the neem lineage. We further identify two BAHD-acetyltransferases (ATs) in chinaberry (MaAT8824 and MaAT1704) that catalyse acetylation at both the C-12 and C-3 hydroxyl groups of limonoids, whereas the syntenic neem copy (AiAT0635) does not possess this activity. A critical N-terminal region (SAGAVP) is crucial for the acetylation of AiAT0635, and swapping it into the MaAT8824 version (CHRSSG) can endow it with acetylation activity. Our improved genome assemblies provide insights into allopatric speciation of neem, as well as limonoid biosynthesis and chemical diversity in meliaceous plants.
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