Evidence map›Paper›PMID 40097348›Full record

ArticlePrenatal diagnosis2025

'When Lightning Strikes Twice'-Preimplantation Genetic Testing for Two Indications in One Biopsy.

Einav Kremer, Hagit Daum, Amy Solnica, Tamar Krisher, Assaf Ben Meir, Efrat Esh-Broder, Mali Ketzinel Gilad, Talya Daniel Mordechai, Tal Imbar

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Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Einav KremerIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Hagit DaumDepartment of Genetics, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Amy SolnicaFaculty of Medicine, Henrietta Szold School of Nursing, Hadassah Medical Center, Hebrew University, Jerusalem, Israel.
Tamar KrisherDepartment of Genetics, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Assaf Ben MeirIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Efrat Esh-BroderIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Mali Ketzinel GiladIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Talya Daniel MordechaiIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Tal ImbarIVF Unit, Department of Obstetrics and Gynecology, Hadassah Medical Organization and Faculty of Medicine, The Hebrew University, Jerusalem, Israel.ORCID 0000-0002-8583-1596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to investigate whether the clinical pregnancy and live birth rates in women undergoing preimplantation genetic testing for two indications (PGT2) differ from PGT for one autosomal dominant indication (PGT1).

methodThis retrospective cohort study summarizes data from 44 PGT patients treated between 2015 and 2023. Data were divided into PGT2 (n = 22 patients, 113 treatment cycles) and PGT1 (n = 22 patients, 108 treatment cycles) groups. Statistical analysis included descriptive statistics, independent t-tests, Mann-Whitney U tests, mixed models, and multivariable mixed logistic regressions.

resultsThe groups did not differ in clinical pregnancy and live birth rates. PGT2 patients had more fresh embryos per cycle than the PGT1 group (4.84 vs. 3.18 respectively; p = 0.067) and a significantly lower number of frozen embryos after biopsy (0.29 vs. 0.60 respectively; p = 0.037). No difference was found regarding the mean suitable embryos for biopsy. The PGT2 group had fewer embryos to transfer per cycle (1.30 vs.1.89; p = 0.007), yet there was no difference regarding the number of transferred embryos per cycle.

conclusionTesting for two genetic indications in one biopsy is feasible yet yields a lower proportion of embryos genetically suitable for transfer but with a similar live birth rate.

Indexed as

Genetic TestingPreimplantation DiagnosisAdultBiopsyEmbryo TransferFemaleFertilization in VitroHumansLive BirthPregnancyPregnancy RateRetrospective Studiescycle parametersgenetic indicationslive birth ratepreimplantation genetic testing

Identifiers

PMID40097348
PMCPMC12054392

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