ArticleBJOG : an international journal of obstetrics and gynaecology2025
The Association Between Medically Assisted Reproduction and Postpartum Depression: A Register-Based Cohort Study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anxiety symptoms following conception through assisted reproductive technology: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Risk of postpartum depression among women with endometriosis: the Norwegian mother, father and child cohort study (MoBa).European journal of epidemiology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveUndergoing medically assisted reproduction (MAR) has been linked to mixed mental health outcomes in women. We investigated the risk of postpartum depression (PPD) among mothers conceiving with MAR compared to mothers conceiving spontaneously.
designRegister-Based Study.
settingDenmark. POPULATION: 125 870 mothers with a PPD screening record who gave birth between 2015 and 2019.
methodsWe linked mothers' PPD screening records to national health registers and defined MAR conception linking childbirths to MAR treatments.
main outcome measuresWe defined PPD as an Edinburgh Postnatal Depression Scale score of ≥ 11. We performed logistic regression on the risk of PPD among mothers who conceived with MAR compared to spontaneous conception and further assessed variations according to duration, type, and indication for MAR.
resultsThe study population included 10 977 mothers with MAR conception and 114 893 with spontaneous conception, of which 767 (7%) and 8767 (8%) had PPD. We found a lower risk (adjusted risk ratio 0.87, 95% CI [0.80-0.93]) of PPD among mothers with MAR conception compared to spontaneous conception, with smaller variations according to type, duration and indication for MAR.
conclusionsWe observed a lower risk of PPD among mothers with MAR conception compared to mothers with spontaneous conception. While it is unlikely that MAR itself is protective of PPD, women who seek MAR may have a strong desire and psychological preparedness for parenthood, which could explain the observed findings. Among mothers conceiving with MAR, PPD risk may vary depending on the type of MAR treatment and underlying reasons for seeking MAR.
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