ArticleRenal failure2025
Correlation between serum complement component 4 levels and tubular atrophy in patients with lupus nephritis.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study is to examine the relationship between serum complement component 4 (C4) levels and tubular atrophy in patients with lupus nephritis (LN).
methodsPatients diagnosed with LN through renal biopsy were retrospectively analyzed and categorized into two groups: the tubular atrophy group (TA group) and the non-tubular atrophy group (non-TA group). Demographic data, clinical characteristics, and pathological findings were compared between the groups. Logistic regression and spline smoothing plot analysis, utilizing the generalized additive mixed model, were employed to investigate the relationship between serum C4 levels and the occurrence of tubular atrophy.
resultsA total of 129 patients were included in the study, with 57 (44.2%) identified as having tubular atrophy (TA group), while the remaining 72 patients did not present with tubular atrophy (non-TA group). Patients in the TA group exhibited higher serum C4 levels (
conclusionSerum C4 levels demonstrate a significant correlation with the presence of tubular atrophy in patients diagnosed with LN.
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