Evidence map›Paper›PMID 40096920›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2025

Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)

Seong Min Lee, Shannon R Cichanski, Nicolas G Pintozzi, Martin Kaufmann, Glenville Jones, Mark B Meyer

Abstract read
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Systemic versus local regulation of vitamin D.Current opinion in nephrology and hypertension · 2026
    Review
  5. Vitamin D and Kawasaki disease.Frontiers in pharmacology · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seong Min LeeDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Shannon R CichanskiDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Nicolas G PintozziDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Martin KaufmannDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L3N6, Canada; Department of Surgery, Queen's University, Kingston, Ontario K7L3N6, Canada.
Glenville JonesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L3N6, Canada.
Mark B MeyerDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: markmeyer@wisc.edu.

Funding

Contribution of nonrenal calcitriol production in chronic inflammationR01HL159645 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MEYER, MARK B · 2021 to 2024
$1.9M
NHLBI NIH HHS R01 HL159645
6 · The paper itself

Abstract

Vitamin D metabolism is controlled through the kidney mitochondrial P450 enzymes 1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1) that activate and degrade the endocrine vitamin D hormone (1,25(OH)

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolKidneyVitamin D3 24-HydroxylaseAnimalsMaleMiceMice, Knockout25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolVitamin D3 24-Hydroxylase1,25(OH)(2)D(3)Cyp24a1Cyp27b1-KOPax8Six2VDRVitamin D

Identifiers

PMID40096920
PMCPMC12496027

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.