Evidence map›Paper›PMID 40096918›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2025

The impact of inducible-whole body or intestine-specific Cyp24a1 gene knockout on vitamin D metabolism in mice.

James C Fleet, Natalie M Watkins, Paul H Anderson, Glenville Jones, Martin Kaufmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Systemic versus local regulation of vitamin D.Current opinion in nephrology and hypertension · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James C FleetDepartment of Nutritional Sciences, University of Texas at Austin, United States. Electronic address: james.fleet@austin.utexas.edu.
Natalie M WatkinsDepartment of Nutritional Sciences, University of Texas at Austin, United States.
Paul H AndersonClincal and Health Sciences University of South Australia, Adelaide, Australia.
Glenville JonesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Martin KaufmannDepartment of Surgery, Queen's University, Kingston, Canada.

Funding

Nutrigenomics of Intestinal Vitamin D ActionR01DK112365 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SYLVIA S CHRISTAKOS, James C. Fleet · 2017 to 2026
$4.2M
Nutrigenetics of Intestinal Ca AbsorptionR01DK118036 · NIDDK · PURDUE UNIVERSITY · PI FLEET, JAMES C. · 2019 to 2020
$956k
NIDDK NIH HHS R01 DK112365NIDDK NIH HHS R01 DK118036
6 · The paper itself

Abstract

Expression of 25 hydroxyvitamin D 24 hydroxylase from the Cyp24a1 gene mediates 1,25 dihydroxyvitamin D (1,25(OH)

Indexed as

Intestinal MucosaVitamin DVitamin D3 24-HydroxylaseAnimalsFemaleKidneyMaleMiceMice, Inbred C57BLMice, KnockoutTamoxifenCyp24a1 protein, mouseTamoxifenVitamin DVitamin D3 24-Hydroxylase25 hydroxyvitamin D 24 hydroxylaseMetabolitesVitamin D

Identifiers

PMID40096918
PMCPMC13493101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.