ArticleJournal of neurosurgery. Case lessons2025
L5 osteotomy combined with adjuvant romosozumab therapy for L5 osteoporotic vertebral fracture-induced spinal deformity: illustrative case.
Article in Journal of neurosurgery. Case lessons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSpinal reconstruction of an L5 osteoporotic vertebral fracture (OVF) is a demanding surgery because of the condition's rarity, poor bone quality, and anatomical reasons. To date, there has been little debate regarding the surgical strategy for L5 OVF and effective osteoporosis treatment. The authors report L5 osteotomy and adjuvant romosozumab (ROMO) therapy for L5 OVF-induced spinal deformity. OBSERVATIONS: A 73-year-old woman underwent lumbopelvic instrumentation and fusion from L3 to the pelvis, L5 osteotomy combined with unilateral posterior vertebral column resection (VCR), followed by expandable cage replacement and bone biopsy simultaneously. Histomorphometric analysis of the bone biopsy showed accelerated bone formation in the endocortical region of the spinous process. After surgery, her low back pain and leg pain improved with satisfactory global alignment. At the 2-year follow-up, lumbopelvic reconstruction achieved fusion, with minimal reciprocal change and no mechanical failure. The patient's Oswestry Disability Index improved from 64% to 24%. L5 osteotomy combined with unilateral VCR and expandable cage replacement was a safe and effective technique in this case. LESSONS: This technique can provide both greater restoration of lower lumbar lordosis and pelvic tilt with fusion. Moreover, adjuvant ROMO therapy has the potential to prevent osteoporosis-related complications. https://thejns.org/doi/10.3171/CASE24633.
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