ArticleLa Tunisie medicale2025
Article in La Tunisie medicale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAt birth, the biological diagnosis of congenital toxoplasmosis (CT) is essentially serological.
aimTo report the results of biological techniques used in the neonatal diagnosis of CT.
methodsThis was a descriptive study including newborns (NB) suspected of having CT who were referred to the Parasitology-Mycology laboratory of the Institut Pasteur of Tunis over a 17-year period. Newborns whose mothers had toxoplasmic infection during pregnancy, with either a negative or unperformed antenatal diagnosis, were included. The search for IgG and IgM antibodies was conducted using ELISA and western blot techniques.
resultsAmong the 224 newborns included, the first sample was taken between days 1 and 3 of life in 58% of cases. In 181 newborns from our series, the disappearance of IgG was observed at an average age of 4.8 ± 1.6 months. IgM was positive after day 10 of life in 11 cases. A comparative mother-newborn western blot was performed for 216 newborns (96.4%). The diagnosis of CT was confirmed in 43 newborns (19.2%): either based on a positive western blot in 30 cases (69.8%), the presence of IgM by ELISA after day 10 of life in 11 cases (25.6%), or the persistence of IgG after 12 months of follow-up in two cases (4.6%).
conclusionOur study confirms the undeniable contribution of the comparative western blot in the diagnosis of CT at birth.
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