Evidence map›Paper›PMID 40096677›Full record

ArticleThe Journal of urology2025

Facilitated Clearance of Small, Asymptomatic Renal Stones With Burst Wave Lithotripsy and Ultrasonic Propulsion.

Jonathan D Harper, Barbrina Dunmire, Jeff Thiel, Barbara H Burke, Yak-Nam Wang, Stephanie Totten, John C Kucewicz, Adam D Maxwell, M Kennedy Hall, Arturo E Holmes and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04796792 (Ultrasound Technology to Fragment and Reposition Urinary Stones), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04796792 narecruitingnot on this map

Ultrasound Technology to Fragment and Reposition Urinary Stones

TypeinterventionalSponsorUniversity of WashingtonRan2023 to 2028Enrolled140ConditionsUrinary Stone, Urinary CalculiArmsBurst Wave Lithotripsy (BWL) and Ultrasonic Propulsion (UP)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jonathan D HarperDepartment of Urology, University of Washington, Seattle, Washington.
Barbrina DunmireCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Jeff ThielCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Barbara H BurkeInstitute of Translational Health Sciences, University of Washington, Seattle, Washington.
Yak-Nam WangCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Stephanie TottenCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
John C KucewiczCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Adam D MaxwellDepartment of Urology, University of Washington, Seattle, Washington.
M Kennedy HallDepartment of Emergency Medicine, University of Washington School of Medicine, Seattle, Washington.
Arturo E HolmesDepartment of Urology, University of Washington, Seattle, Washington.
Christina PopchoiCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
James E LingemanDepartment of Urology, Indiana University School of Medicine, Indianapolis, Indiana.
Alana C DesaiDepartment of Urology, University of Washington, Seattle, Washington.
Robert M SweetDepartment of Urology, University of Washington, Seattle, Washington.
Manjiri DigheDepartment of Radiology, University of Washington, Seattle, Washington.
Branda J LevchakSeattle Institute for Biomedical and Clinical Research, Veterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington.
Claire C YangDepartment of Urology, University of Washington, Seattle, Washington.
Michael R BaileyDepartment of Urology, University of Washington, Seattle, Washington.ORCID 0000-0003-0491-6465
Mathew D SorensenDepartment of Urology, University of Washington, Seattle, Washington.

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI BAILEY, MICHAEL R · 1994 to 2023
$33.5M
NIDDK NIH HHS P01 DK043881
6 · The paper itself

Abstract

purposeWe tested feasibility of burst wave lithotripsy and ultrasonic propulsion to noninvasively fragment and expel small, asymptomatic renal stones in awake participants. MATERIALS AND

methodsAdult patients suspected of having 2- to 7-mm stones were consented and screened for eligibility. Burst wave lithotripsy and ultrasonic propulsion were applied to up to 3 stones in 1 kidney of qualifying participants for a 30-minute total exposure. Participants completed a CT scan and the Wisconsin Stone Quality-of-Life (WISQOL) questionnaire within 90 days before and 120 days after the procedure. Participants were contacted weekly for 3 weeks after the procedure to assess adverse events (AEs). Outcomes included (1) no fragment > 2 mm, (2) unanticipated health care visits, (3) change in stone volume, (4) reported AEs, and (5) WISQOL score.

resultsForty-one participants were enrolled between April 2023 and October 2024. Twenty-one participants failed screening because no stones were seen, stones were too large or small, stone visibility was too deep or obstructed, or they declined to participate. Twenty participants with 31 stones received the research procedure with 7 undergoing a single repeat procedure. Twenty-two of 31 stones (71%) met the primary effectiveness outcome of no fragment > 2 mm, with 17 of 31 stones (55%) reported as stone free. Median stone volume reduction (IQR) was 100% (88%-100%). No participants returned unexpectedly for care related to the procedure. AEs were all grade I by modified Clavien classification. WISQOL scores improved on 10 of 15 completed questionnaires.

conclusionsSmall, asymptomatic renal stones were effectively and safely removed in awake participants in a clinic setting.

Indexed as

Kidney CalculiLithotripsyAdultAgedAsymptomatic DiseasesFeasibility StudiesFemaleHumansMaleMiddle AgedQuality of LifeTreatment Outcomekidney stoneslithotripsyultrasound

Identifiers

PMID40096677
PMCPMC12148704

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.