ArticleThe Journal of urology2025
Negative Predictive Value of a Prostate MRI in Black Men: Implications for Biopsy Decision-Making.
Article in The Journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- MRI and PSMA PET/CT: Foes or friends for the early detection of prostate cancer?Prostate cancer and prostatic diseases · 2026Review
- Reliability of Negative Prostate MRI for Biopsy Decision-Making in the Male Han Chinese Population.Prostate cancer · 2026Article
- Re: Prostate MRI and clinicopathologic risk calculator to predict laterality of extraprostatic extension at radical prostatectomy.Prostate cancer and prostatic diseases · 2025Article
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28 authors.
Funding
Abstract
purposeProstate Imaging Reporting and Data System (PIRADS) v2.1 scoring with multiparametric (mp) MRI has a pooled 90% negative predictive value (NPV). PSA density (PSAD) ≤ 0.15 ng/mL/cm MATERIALS AND
methodsWe prospectively recruited Black and non-Black men referred to outpatient urology clinics for abnormal PSA or prostate examination in 3 similar biomarker validation studies from 2017 to 2023 before MRI-informed diagnostic prostate biopsy. We combined the research cohorts with a retrospective clinical cohort of clinically similar Black and non-Black men from 1 academic institution who also underwent mpMRIs and MRI-informed biopsies. MRIs were scored using PIRADS version 2.0 or 2.1.
resultsOur analysis included 286 Black men and 965 non-Black men with PSA ≤ 15.0 ng/mL. PIRADS < 3 had an NPV of 77.1% vs 87.6% and a sensitivity of 90.7% vs 96.3% for Gleason grade group 2 to 5 prostate cancer in Black vs non-Black men, respectively (both
conclusionsPIRADS < 3 has a lower NPV and sensitivity in Black men. For negative prostate MRIs, PSAD ≥ 0.09 may be a better threshold for safe biopsy deferral in Black men to maintain a ≥ 90% sensitivity.
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