ArticleClinical journal of oncology nursing2025
Updating the Carboplatin Hypersensitivity Protocol: Two Case Studies.
Article in Clinical journal of oncology nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCarboplatin is used to treat gynecologic cancers. Reexposure to carboplatin in the recurrent disease setting increases the risk of hypersensitivity reactions, which can be mild or cause death. A carboplatin desensitization protocol was developed to help with patient tolerance, but no standard protocol existed.
objectivesThis protocol was updated to replace an older desensitization protocol, align with best practices, and bring cost savings to the institution through reduced labor and shortened hospital stays.
methodsThe updated four-bag, four-hour protocol was implemented in patient care on March 8, 2024. A total of five desensitizations were completed. Each desensitization was retrospectively reviewed and assessed for safety and tolerability using the Common Terminology Criteria for Adverse Events.
findingsFive desensitizations successfully occurred for two patients between March 8 and July 13, 2024. Each desensitization saved $108 in pharmacy supply costs and $92 in pharmacy labor costs. Saved nursing costs totaled about $400 for each desensitization.
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