Evidence map›Paper›PMID 40096163›Full record

ArticleJournal of the American Geriatrics Society2025

Functional Trajectories After COVID-19 Hospitalization Among Older Adults.

Jim Q Ho, Gail J McAvay, Terrence E Murphy, Denise Acampora, Katy Araujo, Mary Geda, Thomas M Gill, Alexandra M Hajduk, Andrew B Cohen, Lauren E Ferrante

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jim Q HoDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0009-0001-8343-1310
Gail J McAvaySection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Terrence E MurphyDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-9649-517X
Denise AcamporaSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Katy AraujoSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Mary GedaSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Thomas M GillSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6450-0368
Alexandra M HajdukSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-5800-347X
Andrew B CohenSection of Geriatrics, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-9161-8436
Lauren E FerranteSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-1345-1225

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
The PREDICT Study (PRE-ICU Determinants of Post-ICU FunCTional Outcomes among Older Adults)K76AG057023 · NIA · YALE UNIVERSITY · PI FERRANTE, LAUREN · 2017 to 2022
$1.3M
Dementia and Decision-Making for Older Adults without SurrogatesK76AG059987 · NIA · YALE UNIVERSITY · PI COHEN, ANDREW B · 2018 to 2022
$1.2M
NCATS NIH HHS UL1 TR002014NCATS NIH HHS UL1TR002014NIA NIH HHS K76 AG057023NIA NIH HHS K76AG057023NIA NIH HHS K76 AG059987NIA NIH HHS K76AG059987NIA NIH HHS P30 AG021342NIA NIH HHS P30AG021342NIA NIH HHS P30AG021342-18S1
6 · The paper itself

Abstract

backgroundLittle is known about functional trajectories among older adults who survive hospitalization for coronavirus disease 2019 (COVID-19). We characterized these trajectories over 6 months following discharge and evaluated the associations of potential risk factors with trajectory membership.

methodsParticipants were community-dwelling adults ≥ 60 years of age hospitalized for COVID-19 from June 2020 to June 2021. Interviews completed at 1, 3, and 6 months after discharge included assessments for disability in 15 functional activities. Functional trajectories were identified using latent class analysis. Factors associated with trajectory membership were evaluated using multinomial regression.

results311 participants (mean age 71.3 years) were included. Four different functional trajectories were identified: no (43%), mild (16%), moderate (23%), and severe (18%) disability. The pre-admission count of disabilities was independently associated with membership in each non-reference trajectory. Additional factors independently associated with the moderate trajectory included in-hospital delirium (OR 4.12 [95% CI 1.11-15.4]), frailty (OR 1.67 [95% CI 1.12-2.50]) and number of comorbidities (OR 1.41 [95% CI 1.12-1.79]) and with the severe trajectory included in-hospital delirium (OR 12.4 [95% CI 1.93-79.4]), frailty (OR 2.01 [95% CI 1.11-3.62]), number of comorbidities (OR 1.59 [95% 1.11-2.28]), severity of illness (OR 1.46 [95% CI 1.09-1.95]), and age (OR 1.10 [95% CI 1.02-1.18]).

conclusionsOlder survivors of COVID-19 hospitalization experience distinct functional trajectories. Our findings may help inform shared medical decision-making during and after hospitalization and stimulate further research into modifiable risk factors.

Indexed as

COVID-19HospitalizationActivities of Daily LivingAgedAged, 80 and overDeliriumFemaleFrailtyHumansIndependent LivingMaleMiddle AgedRisk FactorsSARS-CoV-2COVID‐19disabilityfunctiongeriatricshospitalization

Identifiers

PMID40096163
PMCPMC12213203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.