ArticleAmerican journal of physiology. Heart and circulatory physiology2025
No effect of stage 1 hypertension or hypertensive medication on critical environmental limits (PSU HEAT Project).
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Extreme Heat Exposure and Blood Pressure in Community Health Center Patients.JAMA network open · 2026Article
- Recognizing and Mitigating the Effects of Medication on Heat-Related Illness in Older Adults: A Scoping Review.Pharmacy (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Middle-aged and older individuals with hypertension are often considered to be at increased risk during environmental heat waves due to blunted increases in skin blood flow and subsequently elevated core temperatures. In addition, common antihypertensive medications [i.e., angiotensin-converting enzyme (ACE) inhibitors, diuretics, and β blockers] can independently impair heat loss mechanisms, reportedly heightening heat-related risk. If these groups are at increased risk, differences should be observed in the environmental conditions in which thermal balance can occur. Identifying critical environmental limits is an integrative method to determine the conditions that separate safe from unsafe heat exposure. Seventy-two participants (
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Registered trials
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