Evidence map›Paper›PMID 40095332›Full record

Observational studyJapanese journal of ophthalmology2025

Remarkable visual improvement in Leber hereditary optic neuropathy.

Yasuyuki Takai, Akiko Yamagami, Mayumi Iwasa, Kenji Inoue, Ryoma Yasumoto, Hitoshi Ishikawa, Masato Wakakura

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yasuyuki TakaiDepartment of Ophthalmology, Inouye Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. tkysyk3@gmail.com.ORCID http://orcid.org/0000-0001-7971-8258
Akiko YamagamiDepartment of Ophthalmology, Inouye Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Mayumi IwasaDepartment of Ophthalmology, Inouye Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Kenji InoueDepartment of Ophthalmology, Inouye Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Ryoma YasumotoDepartment of Clinical Laboratory, Kitasato University Hospital, Kanagawa, Japan.
Hitoshi IshikawaDepartment of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
Masato WakakuraDepartment of Ophthalmology, Inouye Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLeber hereditary optic neuropathy (LHON) typically has a poor visual outcome. In this study, we examined 8 cases of LHON that demonstrated remarkable visual improvement. STUDY

designRetrospective observational study, clinical case series

methodsWe analyzed the clinical histories and outcomes of 8 patients (16 eyes) whose best corrected visual acuity (BCVA) improved to 0.7 or higher in at least 1 eye.

resultsThe median age of onset of the 7 male patients and 1 female patient was 17 years (range 8-58). Genetic testing revealed m.11778G>A mutations in 6 and m.14484T>C mutations in 2 of the patients. Of the 16 eyes, 15 improved to a BCVA of 0.7 or higher, whilst 1 eye achieved a final BCVA of 0.5. The lowest BCVA was below 0.1 in 12/16 eyes. BCVA improved to 0.1 or better within 1 year in 6/12 eyes and to 0.7 or better within 2 years in 12/15 eyes. In 10 eyes monitored by use of Humphrey Field Analysis (HFA; Fastpac, 30-2 program), the mean deviation improved from - 13.2 dB (- 23.6 to - 4.54) at its lowest to - 5.0 dB (- 15.6 to - 0.9) at the final measurement. Final HFA showed residual defects in the temporal region in 7/16 eyes. In the chronic phase, 10/12 eyes displayed either normal optic disc findings or partial temporal pallor.

conclusionIn LHON cases with remarkable visual improvement, the recovery began earlier, and the visual field defects were relatively mild and tended to persist in the temporal region after improvement. Understanding these cases of notable improvement may inform future treatment strategies.

Indexed as

Optic Atrophy, Hereditary, LeberVisual AcuityVisual FieldsAdolescentAdultChildDNA, MitochondrialDNA Mutational AnalysisFemaleFollow-Up StudiesHumansMaleMiddle AgedMutationRetrospective StudiesTomography, Optical CoherenceDNA, MitochondrialHumphry visual analyzerLeber hereditary optic neuropathyPapillomacular bundleVisual recovery

Identifiers

PMID40095332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.