ArticleJapanese journal of ophthalmology2025
Ocular complication induced by anticancer drug S-1: association with drug concentrations in tears.
Article in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Ocular toxicities associated with anticancer drug therapy in Asian patients: a literature review and practical management recommendations for non-ophthalmologic settings.International journal of clinical oncology · 2026Review
- Surgical procedures and outcomes in patients with tear drainage system disorders associated with the anticancer agent S-1.Japanese journal of ophthalmology · 2026Observational
- Incidence and risk factors related to ocular adverse effects caused by S-1 chemotherapy.Japanese journal of ophthalmology · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeS-1 is an orally active anticancer drug known to cause ocular adverse events (AEs), including lacrimal passage obstruction and corneal complications. This study investigated tear concentrations of 5-fluorouracil (5-FU) and tegafur (FT) in patients receiving S-1 treatment and their relationship with ocular AEs. STUDY
designMulticenter prospective cohort study.
methodsWe recruited patients scheduled for S-1 chemotherapy. After initial ophthalmologic examinations at enrollment, serial examinations were performed during the courses of S-1 administration for up to 1 year. Tear samples were collected using Schirmer test strips at the end of the first course of S-1 treatment. 5-FU and FT concentrations were measured using high-performance liquid chromatography.
resultsThe study cohort comprised 94 patients among whom 38 (40.4%) developed ocular AEs, including 32 (34.0%) corneal AEs, 13 (13.8%) lacrimal AEs, and 7 (7.4%) patients who developed both. The tear FT concentrations in the ocular AE group were significantly higher compared with the group without ocular AEs (3.15 ± 3.09 vs. 1.86 ± 1.56 µg/mL; p = 0.017). There was no difference in tear 5-FU concentration between the 2 groups. The FT concentration in tears in the corneal and lacrimal AE groups was significantly higher than in the group without ocular AEs (p = 0.013 and 0.030, respectively).
conclusionFT concentration in tears due to oral S-1 therapy is associated with corneal or lacrimal AEs. Measuring FT concentration in tears or plasma may be useful for predicting the onset of ocular AEs.
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