Observational studyJapanese journal of ophthalmology2025
Incidence and risk factors of late-onset intraocular pressure elevation after vitrectomy with silicone oil tamponade.
Observational study in Japanese journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the incidence and risk factors of late-onset intraocular pressure (IOP) elevation in patients who underwent pars plana vitrectomy with silicone oil (SO) injection for the management of various vitreoretinal pathologies. STUDY
designA retrospective observational study.
methodsA single-center study involving 135 eyes of 129 patients who underwent vitrectomy with SO injections between January 2018 and May 2023 and maintained SO tamponade for ≥1 month. Eyes with prior glaucoma surgery; a history of SO injection; SO removal or exchange within a month; a follow-up period of <1 month; or those who showed IOP elevation on postoperative day 1 were excluded from the analysis. Late-onset IOP elevation was defined as IOP ≥ 21 mm Hg after postoperative day 7.
resultsLate-onset IOP elevation developed in 22.2% (30/135 eyes) and the mean onset was 38.0±53.4 days (7-251 days) after surgery. In the multivariate logistic regression analysis, late-onset IOP elevation was associated with pre-existing glaucoma (odds ratio [OR], 7.16; P=0.041), longer axial length (OR, 1.40, P=0.037), and higher preoperative IOP (OR, 1.12; P=0.037). Among the patients with late-onset IOP elevation, 50% (15/30) required oral acetazolamide despite the administration of IOP-lowering eye drops. Among them, surgical intervention was required in 8 cases (53.3%).
conclusionLate-onset IOP elevation is a common complication associated with SO tamponade. Risk factors for late-onset IOP elevation are pre-existing glaucoma, longer axial length, and preoperative higher IOP. Since a substantial proportion of eyes require surgical intervention, proactive measures should be considered for effective IOP control.
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