Synthesis of a Set of Staphylococcus Aureus Capsular Polysaccharide Type 1 Oligosaccharides Carrying Taurine Esters.

Kitt Emilie Østerlid, Renata Cergano, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kitt Emilie ØsterlidLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Renata CerganoLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Herman S OverkleeftLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Gijsbert A van der MarelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Jeroen D C CodéeLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.ORCID https://orcid.org/0000-0003-3531-2138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is a Gram-positive bacterium that is responsible for severe nosocomial infections. The protective capsular polysaccharides (CPs), which are key elements of the cell wall, have been proposed as promising candidate antigens. Several CP types have been identified including CP1, CP5, and CP8, and serotype 1 has been associated with increased resistance to phagocytosis and virulence. Here, the synthesis of a set of S. aureus CP 1 (strain M and D) trisaccharides, composed of an α-N-acetyl d-fucosamine and two α-N-acetyl d-galactosaminuronic acid residues, carrying taurine esters together with a nontaurinated hexasaccharide, is reported. To be able to tune the taurine substitution pattern, an orthogonal C-6-OH protecting group strategy for the galactosamine building blocks was developed, in conjunction with a postglycosylation oxidation protocol to site selectively introduce the taurine amide substitutions. The stereoselectivity in the glycosylations was secured using a silylene-protected 2-azido galactose synthon.

Indexed as

Bacterial CapsulesOligosaccharidesPolysaccharides, BacterialStaphylococcus aureusTaurineEstersGlycosylationStereoisomerismEstersOligosaccharidesPolysaccharides, BacterialTaurinecapsular polysaccharidesglycosylationStaphylococcus aureusstereoselectivity

Identifiers

PMID40095323

DOI10.1002/chem.202500132

PMCPMC12043029

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.