Evidence map›Paper›PMID 40095294›Full record

ArticleAdvanced healthcare materials2025

Biofunctionalization of ADA-GEL Hydrogels Based on the Degree of Cross-Linking and Polymer Concentration Improves Angiogenesis.

Stefanie Heltmann-Meyer, Rainer Detsch, Jonas Hazur, Lasse Kling, Sabrina Pechmann, Rajkumar Reddy Kolan, Justus Osterloh, Aldo R Boccaccini, Silke Christiansen, Carol I Geppert and 3 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefanie Heltmann-MeyerDepartment of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Rainer DetschInstitute of Biomaterials, University of Erlangen-Nürnberg, 91058, Erlangen, Germany.
Jonas HazurInstitute of Biomaterials, University of Erlangen-Nürnberg, 91058, Erlangen, Germany.
Lasse KlingInstitute for Nanotechnology and Correlative Microscopy gGmbH (INAM gGmbH), 91301, Forchheim, Germany.
Sabrina PechmannDepartment for Correlative Microscopy and Materials Data, Fraunhofer Institute for Ceramic Technologies and Systems (IKTS), 91301, Forchheim, Germany.
Rajkumar Reddy KolanInstitute for Nanotechnology and Correlative Microscopy gGmbH (INAM gGmbH), 91301, Forchheim, Germany.
Justus OsterlohDepartment of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Aldo R BoccacciniInstitute of Biomaterials, University of Erlangen-Nürnberg, 91058, Erlangen, Germany.
Silke ChristiansenDepartment for Correlative Microscopy and Materials Data, Fraunhofer Institute for Ceramic Technologies and Systems (IKTS), 91301, Forchheim, Germany.
Carol I GeppertInstitute of Pathology, University Hospital of Erlangen, Friedrich-Alexander-Universität, Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Andreas ArkudasDepartment of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Raymund E HorchDepartment of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.
Dominik SteinerDepartment of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany.ORCID 0000-0002-1904-5925

Funding

Deutsche Forschungsgemeinschaft 326 998 133
6 · The paper itself

Abstract

The creation of bioartificial tissues is a promising option for the reconstruction of large-volume defects. The vascularization of tissue engineering constructs, as well as the material properties of the carrier matrix, are important factors for successful clinical application. In this regard, hydrogels are promising biomaterials, providing an extracellular matrix-like milieu that enables the possibility of cell transplantation and de novo tissue formation. Furthermore, biofunctionalization allows for a certain fine-tuning of angiogenic properties. This study aims to investigate vascularization and tissue formation of highly cross-linked alginate dialdehyde (ADA) and gelatin (GEL). This highly cross-linked network is created using a dural cross-linking mechanism combining ionic (Ca

Indexed as

AlginatesHydrogelsNeovascularization, PhysiologicAngiogenesisAnimalsBiocompatible MaterialsCross-Linking ReagentsGelatinHumansRatsTissue EngineeringTissue ScaffoldsTransglutaminasesAlginatesBiocompatible MaterialsCross-Linking ReagentsGelatinHydrogelsTransglutaminasesADA‐GELangiogenesisbiofunctionalizationhydrogeltissue engineering

Identifiers

PMID40095294
PMCPMC12023838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.