Evidence map›Paper›PMID 40095283›Full record

ArticleCEN case reports2025

Human immunodeficiency virus-associated nephropathy mainly due to cellular variant of focal segmental glomerulosclerosis.

Hikaru Tanimizu, Naoki Sawa, Akinari Sekine, Yuki Oba, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kei Kono and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hikaru TanimizuNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan. ravine.hermit0424@gmail.com.ORCID 0009-0008-7378-8122
Naoki SawaNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Akinari SekineNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Yuki ObaNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Masayuki YamanouchiNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Eiko HasegawaNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Tatsuya SuwabeNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Junichi HoshinoNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Keiichi KinowakiDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Kei KonoDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Kenichi OhashiDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.
Yukiko KanetsunaDepartment of Pathology, International University of Health and Welfare, Narita, Japan.
Kazuho HondaDepartment of Anatomy, Showa University School of Medicine, Tokyo, Japan.
Kensuke JohDepartment of Pathology, Jikei University, Minato, Japan.
Yutaka YamaguchiYamaguchi's Pathology Laboratory, Chiba, Japan.
Takehiko WadaNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan.
Yoshifumi UbaraNephrology Center, Toranomon Hospital, 2-2-2, Minato-City, ToranomonTokyo, 105-0001, Japan. ubara@toranomon.gr.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 45-year-old man with a low titer of hepatitis B virus (HBV) was diagnosed with nephrotic syndrome. A subsequent test for human immunodeficiency virus (HIV) was positive. Kidney biopsy revealed some signs of collapsing variant of focal segmental glomerulosclerosis (FSGS), but the predominant finding was a cellular variant of FSGS. Two years after receiving tenofovir, urine protein became negative, and the patient was finally diagnosed with HIV-associated nephropathy. Collapsing variant of FSGS is considered typical of HIV-related nephropathy, but the cellular variant of FSGS in this patient represents another type. The cause of many FSGSs is often never identified, making cause-based treatment difficult. This case demonstrates that identification of the cause of FSGS can lead to treatment of FSGS.

Indexed as

AIDS-Associated NephropathyGlomerulosclerosis, Focal SegmentalHIV InfectionsNephrotic SyndromeBiopsyHumansKidneyMaleMiddle AgedTenofovirTenofovirCellular variant of FSGSCollapsing variant of FSGSFocal segmental glomerulosclerosis (FSGS)HIV-associated nephropathyHuman immunodeficiency virus (HIV)

Identifiers

PMID40095283
PMCPMC12126410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.