Evidence map›Paper›PMID 40095270›Full record

ArticleReproduction in domestic animals = Zuchthygiene2025

Identifying Key Genetic Factors Influencing Reproductive Performance in Dairy and Meat Sheep Breeds of the Mediterranean Region.

Maria Consuelo Mura, Giovanni Cosso, Mortadha Ouadday, Chadi Hosri, Joze Starič, Michella Nehme, Vincenzo Carcangiu, Sebastiano Luridiana

Abstract read
In one paragraph

Article in Reproduction in domestic animals = Zuchthygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Novel Silent Mutations in theAnimals : an open access journal from MDPI · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Consuelo MuraDepartment of Veterinary Medicine of Sassari, University of Sassari, Sassari, Italy.ORCID https://orcid.org/0000-0001-6188-9841
Giovanni CossoAgris Sardegna, Sassari, Sassari, Italy.
Mortadha OuaddayNational School of Veterinary Medicine, Sidi Thabet, University of Manouba, La Manouba, Tunisia.
Chadi HosriAgriculture, Lebanese University, Dekwaneh, Lebanon.
Joze StaričClinic for Reproduction and Large Animals-Section for Ruminants, University of Ljubljana, Ljubljana, Slovenia.
Michella NehmeEngineering, Holy Spirit University of Kaslik, Jounieh, Lebanon.
Vincenzo CarcangiuDepartment of Veterinary Medicine of Sassari, University of Sassari, Sassari, Italy.
Sebastiano LuridianaDepartment of Veterinary Medicine of Sassari, University of Sassari, Sassari, Italy.

Funding

University of Sassari Research Fund FAR2020
6 · The paper itself

Abstract

This study aimed to detect genetic variations in key genes (BMPR1B, BMP15 and GDF9) that influence crucial reproductive traits, such as lambing rate and litter size in sheep. Understanding the genetic basis of these traits is essential for developing more efficient breeding strategies and selecting superior breeding stock, ultimately contributing to improved reproductive efficiency across different sheep breeds, production purposes and farming systems. We examined polymorphisms in the above genes across 500 adult ewes from three Mediterranean countries. The studied breeds included high-yielding dairy (Sarda), dual-purpose with a meat focus (Awassi) and medium-to-low dairy and meat breeds (Slovenian Bovška, Istrian Pramenka and Jezersko-Solčavska). Genetic variations were analysed and correlated with reproductive efficiency, including the interval in days from ram introduction to lambing based on lambing dates. This was used to assess the potential influence of these genes on follicular maturation and oocyte developmental competence. The analysis identified 15 polymorphisms distributed differently among the breeds, with the Sarda exhibiting 11 SNPs and the Awassi 13. The Slovenian breeds showed distinct genetic variation patterns potentially linked to their production goals. However, no significant association was observed between the identified polymorphisms and the analysed reproductive traits. Further studies on other genes regulating bone morphogenetic protein expression, such as the Gremlin 1 (GREM1) gene, may provide additional insights into the genetic mechanisms underlying reproductive traits.

Indexed as

ReproductionSheep, DomesticAnimalsBone Morphogenetic Protein 15Bone Morphogenetic Protein Receptors, Type IBreedingFemaleGenetic VariationGrowth Differentiation Factor 9Litter SizeMediterranean RegionPolymorphism, Single NucleotideBone Morphogenetic Protein 15Bone Morphogenetic Protein Receptors, Type IGrowth Differentiation Factor 9fecundity geneslambing ratelitter sizeMediterranean sheepreproductive performances

Identifiers

PMID40095270
PMCPMC11912815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.