Evidence map›Paper›PMID 40095239›Full record

ArticleJournal of veterinary internal medicine

Multimodal Treatment of a Peripheral Primitive Neuroectodermal Tumor Originating From the Thoracic Cavity in a Dog.

Leah H Ackerman, Madison Toonder, Sarah Bosch, Varvara B Semenova, Timothy P Spicer, Oscar Alas, Lily S Thorsen, Aitor Gallestegui Menoyo, Valentina B Stevenson, Jishnu Rao Gutti and 9 more

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The value of case reports.Frontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Leah H AckermanDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.ORCID https://orcid.org/0009-0008-0021-3328
Madison ToonderDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Sarah BoschDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Varvara B SemenovaDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Timothy P SpicerDepartment of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute, Jupiter, Florida, USA.
Oscar AlasDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.ORCID https://orcid.org/0009-0001-8841-0076
Lily S ThorsenDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Aitor Gallestegui MenoyoDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Valentina B StevensonDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Jishnu Rao GuttiDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Paulo Vilar SaavedraDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Rebecca NanceDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Bakash SahayDepartment of Infectious Diseases & Immunology, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Gabriela P HeryDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Ann M ChanDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Marc E SaluteDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.
Nesrine BensilmaneDepartment of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute, Jupiter, Florida, USA.
Virneliz Fernandez VegaDepartment of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute, Jupiter, Florida, USA.
Rowan J MilnerDepartment of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-6379-2058

Funding

Milner Comparative Oncology Lab
6 · The paper itself

Abstract

Peripheral primitive neuroectodermal tumor (pPNET) is a very rare, highly malignant tumor encountered in young dogs, with only four necropsy cases in the veterinary literature. A 1.5-year-old male intact French Bulldog presented for evaluation of progressive left forelimb lameness and ipsilateral Horner's syndrome. Whole body computed tomography identified a 12 cm mediastinal mass with extension into the vertebral canal and multifocal metastatic lesions. Histological and immunohistochemical results were consistent with a pPNET. Chemotherapy, radiation therapy, immunotherapy, and targeted therapy were administered. Precision-based tumor testing, including DNA sequencing and chemosensitivity assays, were performed to guide systemic treatment recommendations. A partial remission was observed 3.5 months from presentation based on imaging and improved clinical status. After 7 months of treatment, diffuse metastatic disease, including intracranial spread, was observed and the dog was euthanized.

Indexed as

Dog DiseasesNeuroectodermal TumorsAnimalsDogsEuthanasia, AnimalMaleAskin's tumorcancerchemotherapydogprecision medicineprimordial neoplasia

Identifiers

PMID40095239
PMCPMC11912019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.