Evidence map›Paper›PMID 40095237›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2025

A New Automated Ultrasound Quantification of Urethral Mobility for Stress Urinary Incontinence: A Feasibility Study.

Kourosh Kalayeh, J Brian Fowlkes, Bryan S Sack, Jennifer LaCross, Stephanie Daignault-Newton, Payton Schmidt, Haowei Tai, William W Schultz, James A Ashton-Miller, John O DeLancey

Abstract read
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kourosh KalayehDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-5254-6705
J Brian FowlkesDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Bryan S SackDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Jennifer LaCrossDepartment of Obstetrics and Gynecology, University of Michigan, University of Michigan, Ann Arbor, Michigan, USA.
Stephanie Daignault-NewtonDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Payton SchmidtDepartment of Obstetrics and Gynecology, University of Michigan, University of Michigan, Ann Arbor, Michigan, USA.
Haowei TaiDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
William W SchultzDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
James A Ashton-MillerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
John O DeLanceyDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Development of 21st Century Concepts and Tools for Quantifying Urethral Failure Mechanisms that Cause Urinary IncontinenceRC2DK122379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, DELANCEY, JOHN O.L. · 2019 to 2024
$5.7M
Training CoreTL1DK136046 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Laura H Mariani · 2022 to 2026
$2.5M
University of Michigan Kidney, Urology and Hematology Research Training NetworkU2CDK129445 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Subramaniam Pennathur · 2022 to 2026
$2.0M
NIA NIH HHS P30 AG024824NIDDK NIH HHS RC2 DK122379NIDDK NIH HHS TL1 DK136046NIDDK NIH HHS U2C DK129445NIH 5 RC2 DK122379-05NIH 5TL1DK136046-03NIH 5U2CDK129445-03
6 · The paper itself

Abstract

objectivesStress urinary incontinence (SUI) is a prevalent condition that can significantly affect quality of life. Urethral mobility is an important factor in SUI and transperineal ultrasound (TPUS) imaging can provide clear visualization of this movement; however, its quantification has been limited. An automated system to track and quantify urethral movement could provide richer information and reduce inter-observer effects on measurements.

methodsAs proof-of-concept for technique development, we used TPUS cine loops obtained on commercial scanners (GE Healthcare and Philips Healthcare) from consented research volunteers. We developed the tracking software based on fundamental concepts from computer vision, specifically corner detection and optical flow-based tracking algorithms. In doing so we account for inadvertent probe movements by using the symphysis pubis as a reference coordinate system.

resultsThe system successfully tracks the motion of the urethra during Valsalva maneuvers. It accurately captures and quantifies complex movements, including directional shifts, rotations, displacement vectors of different structures, and the trajectory of motion. These measurements are corrected for any probe movement. We demonstrated the system's efficiency and reliability in near real-time analysis across various ultrasound platforms and video formats. The intraclass correlation coefficients exceeded 0.89 and 0.5 for intra- and inter-rater reliability, respectively.

conclusionsBy providing detailed, objective measurements of urogenital movement, this approach has potential to advance the understanding, diagnosis and treatment of SUI, which in turn, can help tailor more effective treatment strategies. This methodology paper confirms the feasibility of automated quantification of urethral mobility.

Indexed as

UrethraUrinary Incontinence, StressAdultFeasibility StudiesFemaleHumansReproducibility of ResultsUltrasonographycomputer visionfemale pelvic floorimage processingpelvic floor muscle contractionstress urinary incontinencetransperineal ultrasoundurogenital mobility

Identifiers

PMID40095237
PMCPMC12149724

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.