ArticleJournal of ophthalmic inflammation and infection2025
Controversies in the management of endophthalmitis: a 5-year retrospective cohort study.
Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Retrospective analysis of the clinical characteristics of childhood ocular trauma, 2020-2024.BMC ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePost-operative endophthalmitis has a risk of vision loss if the treatment is delayed. Managing endophthalmitis based on visual outcome has become controversial. This study primarily aimed to evaluate the effectiveness of early pars plana vitrectomy (PPV) combined with intravitreal antibiotics in improving visual acuity and reducing complications in patients with post-operative endophthalmitis. Secondary objectives included identifying prognostic factors influencing visual outcomes after PPV, assessing the effectiveness of different intravitreal antibiotic regimens on visual recovery, and evaluating the role of steroid as adjunctive therapy in influencing visual outcome and controlling inflammation.
methodsA 5-year retrospective cohort study was conducted, reviewing medical records of patients diagnosed with post-operative endophthalmitis between 2019 and 2023. Data collected included patient demographics, medical and surgical history, culture results, treatments administered, baseline best-corrected visual acuity (BCVA), and BCVA outcomes within three months after vitrectomy.
results40 eyes of 40 patients with acute post-operative endophthalmitis underwent early PPV followed by intravitreal antibiotics. Median logMAR BCVA improved from 2.0 at presentation to 0.4 three months post-vitrectomy (p < 0.05), with a mean final logMAR BCVA of 0.94 ± 1.13. No significant difference was observed in visual outcomes or complication rates between patients treated with intravitreal vancomycin and ceftazidime versus moxifloxacin monotherapy. Univariate analysis identified high intraocular pressure (p = 0.004, β = 2.42), hypopyon (p = 0.01, β = 1.79), and a history of surgery more than seven days prior (p = 0.032, β = 1.74) as significant predictive of visual outcomes. Multivariate analysis confirmed intraocular pressure (p = 0.008, β = 2.55) and surgical history (p = 0.045, β = 1.84) as independent predictors. Baseline BCVA, fibrin, retinal findings, and symptom onset were not significantly associated with outcomes. Neither antibiotics regimen nor steroid use significantly influenced treatment results.
conclusionThis study supports performing early PPV combined with intravitreal antibiotics as an effective primary treatment to improve visual outcomes in post-operative endophthalmitis. Negative prognostic factors included hypopyon, elevated intraocular pressure, and a surgical history of more than seven days. Management should prioritize clinical signs over microbiological culture results to prevent delays in treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.