Evidence map›Paper›PMID 40095122›Full record

SynthesisCurrent pain and headache reports2025

A Systematic Review of Sacroiliac Joint Injections of Platelet-Rich Plasma (Prp) and Stem Cells.

Laxmaiah Manchikanti, Alan D Kaye, Alaa Abd-Elsayed, Mahendra R Sanapati, Vidyasagar Pampati, Sahar Shekoohi, Joshua A Hirsch

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. General Innovations in Pain Management.Journal of clinical medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laxmaiah ManchikantiPain Management Centers of America, Paducah, KY, USA.ORCID http://orcid.org/0000-0002-4201-9063
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA.ORCID http://orcid.org/0000-0003-2464-0187
Alaa Abd-ElsayedUW Health Pain Services and University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-9890-7860
Mahendra R SanapatiPain Management Centers of America, Evansville, IN, USA.ORCID http://orcid.org/0000-0002-1047-0765
Vidyasagar PampatiPain Management Centers of America, Paducah, KY, USA.ORCID http://orcid.org/0009-0009-1701-8382
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, USA. sahar.shekoohi@lsuhs.edu.ORCID http://orcid.org/0009-0007-4545-4523
Joshua A HirschMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5263-6535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review evaluates the effectiveness of sacroiliac joint injections of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) for treating low back and lower extremity pain. A systematic analysis was conducted to assess the impact of PRP and MSC injections on managing these conditions. RECENT

findingsIn recent years, several cell-based therapies, including the injection of MSCs and PRP into the sacroiliac joints, have been proposed for the management of low back pain. Emerging clinical evidence supporting their use appears promising. The present systematic review identified 2 randomized controlled trials (RCTs) and 3 observational studies that met inclusion criteria based on strict methodological quality and bias assessments. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework and qualitative analysis synthesis determined evidence levels as IV (limited) with a weak recommendation.

Indexed as

Low Back PainMesenchymal Stem Cell TransplantationPlatelet-Rich PlasmaSacroiliac JointHumansInjections, Intra-ArticularChronic low back painMesenchymal stem cellsPlatelet-rich plasmaRegenerative therapySacroiliac joint injectionsSacroiliac joint pain

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.