Evidence map›Paper›PMID 40095052›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Suppression of necroptosis-driven cell death and inflammation in hypoxic neuroblastoma (SH-SY5Y) cells by necrostatin-1.

Amal Majed H Alenad, Mohd Shahnawaz Khan, Nojood Al-Twaijry, Majed S Alokail, Leon Bernet Shano, Subramani Karthikeyan, Huma Naz, Bigyan Ranjan Jali

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amal Majed H AlenadDepartment of Biochemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia.
Mohd Shahnawaz KhanDepartment of Biochemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia. moskhan@ksu.edu.sa.
Nojood Al-TwaijryDepartment of Biochemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia.
Majed S AlokailDepartment of Biochemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia.
Leon Bernet ShanoDivision of Physics, School of Advanced Science, Vellore Institute of Technology (VIT) Chennai Campus, Vandalur- Kelambakkam Road, Chennai, Tamil Nadu, 600 127, India.
Subramani KarthikeyanCentre for Healthcare Advancement, Innovation and Research, Vellore Institute of Technology University, Vandalur- Kelambakkam Road, Vellore, Tamil Nadu, 600 127, India.
Huma NazDepartment of Internal Medicine, University of Missouri, Mizzou, Columbia, MO, 65211, USA.
Bigyan Ranjan JaliDepartment of Chemistry, Veer Surendra Sai University of Technology Burla Sambalpur Odisha, Burla, 768018, India. bigyan.jali7@gmail.com.

Funding

Research Supporting Project King Saud University, Riyadh, Kingdom of Saudi Arabia, RSP2025R352
6 · The paper itself

Abstract

Neuroblastoma (NB) is the most typical malignant extracranial solid tumor in the pediatric population. The advent of drug resistance is an essential deterrent in treating high-risk NB patients despite a multi-modality remedy. Inflammation-induced early neuronal degeneration plays a leading part in the pathogenesis of NB via necroptosis; however, the mechanisms remained cryptic. Our current investigation determines the anti-inflammatory and neuroprotective effect of necroptosis inhibitor necrostatin-1 (Nec-1) in receptor-interacting proteins 1 and 3 (RIP1/3)-induced cell death pathway and inflammation caused by hypoxia mimetic agent cobalt chloride (CoCl

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsImidazolesIndolesInflammationNecroptosisNeuroblastomaCell DeathCell Line, TumorCobaltHumansNuclear Pore Complex ProteinsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRNA-Binding ProteinsAGFG1 protein, humanAnti-Inflammatory AgentsAntineoplastic AgentsCobaltcobaltous chlorideImidazolesIndolesMLKL protein, humannecrostatin-1Nuclear Pore Complex ProteinsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanRNA-Binding ProteinsHypoxiaInflammationNecroptosisNecrostatin (Nec-1)Neuroblastoma

Identifiers

PMID40095052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.